Zinc protoporphyrin/heme ratio for diagnosis of preanemic iron deficiency
Zinc protoporphyrin/heme ratio for diagnosis of preanemic iron deficiency
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DOI：
10.1542/peds.104.3.e37
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发表时间：
1999-09-01
期刊：
影响因子：
8
通讯作者：
Labbé, RF
中科院分区：
文献类型：
--
作者：
Rettmer, RL;Carlson, TH;Labbé, RF
客观的。众所周知，缺铁性贫血会损害认知和精神运动发育。锌原卟啉/血红素 (ZPP/H) 比率是一种简单、准确且灵敏的实验室筛查测试，可检测贫血发作前的早期铁耗竭。这项工作的目的是在初级儿科实践环境中评估该测试。方法。在社区儿科诊所的常规检查中对 361 名儿童的铁状况进行了筛查。测量全血血红蛋白浓度、血细胞比容比、血清转铁蛋白饱和度、铁蛋白浓度和ZPP/H比值。然后，通过将 ZPP/H 比率与其他检测铁缺乏发作和监测补铁后恢复情况的测试进行比较，将 ZPP/H 比率作为铁状态的单一指标进行评估。结果。发现 ZPP/H 比率与年龄和性别相关的显着差异。在该队列中，血清铁蛋白浓度和 ZPP/H 比率独立地识别出相同比例的缺铁患者 (3%-4%)，并且这两项测试比血红蛋白或血细胞比容更具特异性。三个铁状态参数的一致性将铁缺乏的预测更改为小于或等于 1%。孩子们
Objective. Iron deficiency anemia is known to impair cognitive and psychomotor development. The zinc protoporphyrin/heme (ZPP/H) ratio is a simple, accurate, and sensitive laboratory screening test that detects early iron depletion before the onset of anemia. The objective of this work was to evaluate this test in a primary pediatric practice setting.Methods. The iron status of a cohort of 361 children was screened during routine examinations at a community pediatric practice. Whole blood hemoglobin concentration, hematocrit ratio, serum transferrin saturation, ferritin concentration, and the ZPP/H ratio were measured. The ZPP/H ratio then was evaluated as a single indicator of iron status by comparing it with other tests for detecting the onset of iron deficiency and for monitoring recovery after iron supplementation.Results. Significant age- and sex-related differences in the ZPP/H ratio were found. In this cohort, serum ferritin concentration and the ZPP/H ratio independently identified the same fraction of iron-deficient patients (3%-4%), and both tests were more specific than was either hemoglobin or hematocrit. A concordance of three iron status parameters changed the prediction of iron deficiency to less than or equal to 1%. Children