THE EFFECT OF PENTOBARBITAL-ANESTHESIA ON THE AUTONOMIC NERVOUS-SYSTEM CONTROL OF HEART-RATE DURING BARORECEPTOR ACTIVATION
THE EFFECT OF PENTOBARBITAL-ANESTHESIA ON THE AUTONOMIC NERVOUS-SYSTEM CONTROL OF HEART-RATE DURING BARORECEPTOR ACTIVATION
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DOI：
10.1016/0165-1838(91)90106-d
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发表时间：
1991-11-01
期刊：
影响因子：
--
通讯作者：
MAIXNER, W
中科院分区：
文献类型：
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作者：
WATKINS, L;MAIXNER, W
本研究观察了戊巴比妥钠麻醉对压力感受器介导的反射性心动过缓大鼠自主神经系统控制的影响。在清醒和戊巴比妥钠麻醉(PA)大鼠，用β-1受体拮抗剂阿替洛尔阻断交感神经，或用外周作用的M受体拮抗剂甲基阿托品阻断副交感神经，以苯肾上腺素诱导的高血压诱发反射性心动过缓。戊巴比妥钠麻醉可明显减少反射性心动过缓。在清醒大鼠和PA大鼠中，心交感神经阻断对压力感受性反射增益的影响相当。相反，与清醒大鼠相比，用甲基阿托品阻断副交感神经系统对PA大鼠压力感受性反射增益的抑制相对较少。这些结果表明，戊巴比妥钠麻醉通过抑制迷走神经介导的反射性心动过缓来减少压力感受性反射获得。
This study determined the influence of pentobarbital anesthesia on the autonomic nervous system control of baroreceptor mediated reflex bradycardia in the rat. Reflex bradycardia was elicited by phenylephrine-induced hypertension in conscious and pentobarbital anesthetized (PA) rats before and after sympathetic blockade with the beta-1 receptor antagonist atenolol or parasympathetic blockade with the peripherally acting muscarinic receptor antagonist methyl-atropine. Reflex bradycardia was significantly decreased by pentobarbital anesthesia. Cardiosympathetic blockade produced equivalent relative decreases in baroreflex gain in conscious and PA rats. In contrast, parasympathetic nervous system blockade with methyl-atropine produced relatively less inhibition of baroreflex gain in the PA rat compared with the conscious rat. These results suggest that pentobarbital anesthesia decreases baroreflex gain by inhibiting vagally mediated reflex bradycardia.