PET/MRI hybrid imaging: devices and initial results
PET/MRI hybrid imaging: devices and initial results
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DOI：
10.1007/s00330-008-0857-5
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发表时间：
2008-06-01
影响因子：
5.9
通讯作者：
Wehrl, Hans F.
中科院分区：
文献类型：
--
作者：
Pichler, Bernd J.;Judenhofer, Martin S.;Wehrl, Hans F.
功能和形态成像技术的结合，如正电子发射断层扫描(PET)和X射线计算机断层扫描(CT)，已显示出其在临床和临床前领域的价值。然而，CT只提供非常有限的软组织对比度，并将接受检查的患者或实验动物暴露在高X射线辐射剂量下。与CT相比，磁共振断层成像(MRI)提供了良好的软组织对比，并允许进行核磁共振波谱(NMRS)或功能磁共振成像(FMRI)。因此，PET和MRI的结合已经被追求了几年。第一种方法已经成功地使用传统的光电倍增管(PMT)技术和光纤一起将闪烁光从高磁场中转移出去。最新的PET/MRI开发使用了固态光探测器，即使在高磁场下也可以操作。动物PET/MRI原型系统的初步初步研究显示，将高分辨率形态与多功能信息同步结合，结果令人振奋。
The combination of functional and morphological imaging technologies such as positron emission tomography (PET) and X-ray computed tomography (CT) has shown its value in the clinical and preclinical field. However, CT provides only very limited soft-tissue contrast and exposes the examined patient or laboratory animal to a high X-ray radiation dose. In comparison to CT, magnetic resonance tomography (MRI) provides excellent soft-tissue contrast and allows for nuclear magnetic resonance spectroscopy (NMRS) or functional MRI (fMRI). Thus, the combination of PET and MRI has been pursued for several years. First approaches have succeeded using conventional photo multiplier tube (PMT) technology together with light fibers to transfer scintillation light away from the high magnetic field. Latest PET/MRI developments use solid-state light detectors that can be operated even at high magnetic fields. Initial pilot studies with prototype animal PET/MRI systems have shown promising results by combining high resolution morphology with multifunctional information isochronously.