Prescription opioid and benzodiazepine misuse is associated with suicidal ideation in older adults.
Prescription opioid and benzodiazepine misuse is associated with suicidal ideation in older adults.
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DOI：
10.1002/gps.4999
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发表时间：
2019-01
影响因子：
4
通讯作者：
McCabe SE
中科院分区：
文献类型：
--
作者：
Schepis TS;Simoni-Wastila L;McCabe SE
老年人自杀是一个重大的公共卫生问题。过去在美国成年人群中进行的研究将处方药滥用与自杀意念联系起来。没有工作评估处方阿片类药物或苯二氮卓类药物滥用与老年人自杀意念之间的关联，这项工作旨在解决这一差距。数据来自参与2015 - 16年全国药物使用和健康调查的50岁及以上成年人（n = 17，608）。基于设计的logistic回归评估了过去一年中任何处方阿片类药物或苯二氮卓类药物使用（无误用或处方误用）与过去一年自杀意念之间的联系，控制了与自杀意念相关的社会人口统计学、身体健康、心理健康和药物使用相关性。在控制了所有相关因素后，过去一年未滥用处方阿片类药物或苯二氮卓类药物的使用与老年人过去一年的自杀意念无关。相反，即使在控制了所有协变量后，过去一年阿片类药物滥用（AOR = 1.84，95% CI = 1.07 - 3.19）和苯二氮卓类药物滥用（AOR = 2.00，95% CI = 1.01 - 3.94）与过去一年自杀意念显著相关。虽然2.2%的未滥用阿片类药物或苯二氮卓类药物的美国老年人报告了去年的自杀意念，但25.4%的滥用这两种药物的人支持这种自杀倾向（AOR = 4.73，95% CI = 2.07 - 10.79）。过去一年处方阿片类药物和苯二氮卓类药物滥用与美国老年人过去一年的自杀意念相关。临床医生遇到老年患者的风险或从事处方药滥用也应该筛选自杀倾向。
Suicide in older adults is a major public health issue. Past research across the US adult population has linked prescription medication misuse with suicidal ideation. No work has evaluated associations between prescription opioid or benzodiazepine misuse and suicidal ideation in older adults, and this work aimed to address that gap. Data were from adults 50 years and older participating in the 2015-16 National Survey on Drug Use and Health (n = 17,608). Design-based logistic regression evaluated links between any past-year prescription opioid or benzodiazepine use without misuse or prescription misuse and past-year suicidal ideation, after controlling for sociodemographic, physical health, mental health and substance use correlates associated with suicidal ideation. After controlling for all correlates, past-year use without misuse of prescription opioids or benzodiazepines were not associated with past-year suicidal ideation in older adults. In contrast, past-year opioid misuse (AOR = 1.84, 95% CI = 1.07-3.19) and benzodiazepine misuse (AOR = 2.00, 95% CI = 1.01-3.94) were significantly associated with past-year suicidal ideation, even after controlling for all covariates. While 2.2% of US older adults not engaged in either opioid or benzodiazepine misuse reported past-year suicidal ideation, 25.4% of those who misused both medication classes endorsed such suicidality (AOR = 4.73, 95% CI = 2.07-10.79). Both past-year prescription opioid and benzodiazepine misuse are associated with past-year suicidal ideation in US older adults. Clinicians encountering older adult patients at-risk for or engaged in prescription medication misuse also should screen for suicidality.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1001/jama.2016.1464
发表时间：
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期刊：
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影响因子：
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影响因子：
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