EEG and seizures in autistic children and adolescents: Further findings with therapeutic implications
EEG and seizures in autistic children and adolescents: Further findings with therapeutic implications
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DOI：
10.1177/155005940503600105
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发表时间：
2005-01-01
影响因子：
2
通讯作者：
Melyn, M
中科院分区：
文献类型：
--
作者：
Hughes, JR;Melyn, M
本研究的目的是调查癫痫的发病率，以及自闭症儿童（A）的EEG结果，并将这些数据与EEG对照组进行比较。脑电图定量癫痫样活动的程度，也慢波异常。异常脑电图被发现在75%的59 A儿童和82%的151脑电图，46%的临床癫痫发作。几乎所有癫痫发作的儿童都有癫痫样活动，但几乎20%的棘波放电儿童没有临床发作。与对照组相比，A组的慢波异常更频繁，严重程度更高。一个新的发现是，在A组中发现EEG异常的变异性更大。治疗的影响，根据这些后者的研究结果，进行了讨论。
The goal of this study was to investigate the incidence of epilepsy and also the EEG findings among children with autism (A), a devastating disorder, and to compare these data to an EEG control group. EEGs were quantified as to the degree of epileptiform activity and also slow wave abnormalities. Abnormal EEGs were found in 75% of the 59 A children and 82% of their 151 EEGs; 46% had clinical seizures. Nearly all children with seizures had epileptiform activity, but almost 20% of those with spike discharges did not have clinical attacks. Slow wave abnormalities were more frequent and of a greater degree of severity in the A group, compared to controls. One new finding was that a greater variability of EEG abnormalities was found in the A group. Therapeutic implications, based on these latter findings, are discussed.