Slow glycinergic transmission mediated by transmitter pooling.
Slow glycinergic transmission mediated by transmitter pooling.
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DOI：
10.1038/nn.2265
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发表时间：
2009-03
影响因子：
25
通讯作者：
Trussell, Laurence O.
中科院分区：
文献类型：
--
作者：
Balakrishnan, Veeramuthu;Kuo, Sidney P.;Roberts, Patrick D.;Trussell, Laurence O.
大多数快速作用的神经递质从突触区域迅速清除。这一特征隔离了突触部位，使得突触反应的时间进程与活动突触的数量无关。我们描述了一个惊人的例外，在大鼠耳蜗背核颗粒细胞上的甘氨酸能突触。IPSC的持续时间取决于被刺激的突触前轴突的数量和从每个轴突释放的囊泡的数量。增加刺激数量或频率，或阻断甘氨酸摄取，减缓突触衰减，而GlyRs的低亲和力竞争性拮抗剂加速IPSC衰减。这些效应可以通过GlyRs的独特特征来解释，当GlyRs被跨突触的甘氨酸汇集激活时。在功能上，增加IPSP的数量显着延长了突触前刺激停止后的尖峰抑制期。因此，抑制的时间特性可以通过多个突触前细胞的活动水平或通过调节单个突触的释放概率来控制。
Most fast-acting neurotransmitters are rapidly cleared from synaptic regions. This feature isolates synaptic sites, rendering the timecourse of synaptic responses independent of the number of active synapses. We describe a striking exception at glycinergic synapses on granule cells of the rat dorsal cochlear nucleus. The duration of IPSCs was dependent on the number of presynaptic axons that were stimulated and on the number of vesicles released from each axon. Increasing stimulus number or frequency, or blocking glycine uptake, slowed synaptic decays, while a low-affinity competitive antagonist of GlyRs accelerated IPSC decay. These effects could be explained by unique features of GlyRs when activated by pooling of glycine across synapses. Functionally, increasing the number of IPSPs markedly lengthened the period of spike inhibition following cessation of presynaptic stimulation. Thus, temporal properties of inhibition can be controlled by activity levels in multiple presynaptic cells or by adjusting release probability at individual synapses.
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单个海马GABA能突触的突触后反应的释放概率依赖性尺度。
DOI：
10.1523/jneurosci.3106-06.2006
发表时间：
2006-11-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Biró AA;Holderith NB;Nusser Z
通讯作者：
Nusser Z
影响因子：
5.3
作者：
Carter, AG;Regehr, WG
通讯作者：
Regehr, WG
影响因子：
2.4
作者：
Alibardi, L
通讯作者：
Alibardi, L
影响因子：
5.5
作者：
KATZ, B;MILEDI, R
通讯作者：
MILEDI, R
影响因子：
2.5
作者：
Kinney, GA;Overstreet, LS;Slater, NT
通讯作者：
Slater, NT