Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation.
Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation.
复制标题
牙齿形成过程中转化生长因子-β信号通路介导的空间信号传导
DOI：
10.1038/ijos.2016.45
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发表时间：
2016-12-16
影响因子：
14.9
通讯作者：
中科院分区：
文献类型：
--
作者：
Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like structures after losing the positional information provided by the epithelial and mesenchymal tissues. However, the particular stage in which the tooth germ cells start to form tooth-like structures after losing their positional information remains unclear. In this study, we investigated the reassociation of tooth germ cells suspension from different morphological stages during tooth development and the phosphorylation of Smad2/3 in this process. Four tooth morphological stages were designed in this study. The results showed that tooth germ cells formed odontogenic tissue at embryonic day (E) 14.5, which is referred to as the cap stage, and they formed tooth-like structures at E16.5, which is referred to as the early bell stage, and E18.5, which is referred to as the late bell stage. Moreover, the transforming growth factor-β signalling pathway might play a role in this process.
