Rates for breast cancer characteristics by estrogen and progesterone receptor status in the major racial/ethnic groups
Rates for breast cancer characteristics by estrogen and progesterone receptor status in the major racial/ethnic groups
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DOI：
10.1023/a:1016361932220
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发表时间：
2002-08-01
影响因子：
3.8
通讯作者：
Anderson, WF
中科院分区：
文献类型：
--
作者：
Chu, KC;Anderson, WF
据报道，年龄特异性乳腺癌发病率因雌激素受体和孕激素受体状态而异。我们报告了六个主要种族/民族的乳腺癌发病率，包括诊断年龄、诊断阶段、组织学分级和雌激素（ER）和孕激素（PgR）受体状态的类型。雌激素受体阳性（ER+）、ER-、孕激素受体阳性（PgR(+)）、PgR（-）、ER(+)PgR（+）、ER(+)PgR（-）、ER(+)PgR（-）、ER(-)PgR（+）、ER(-)PgR（+）和ER(-)PgR（-）乳腺癌的平均年年龄调整率来自11个监测、流行病学和最终结果（SEER）癌症登记处1992年至1998年诊断的123,732例已知ER状态的乳腺癌。对于每个种族/民族，他们的ER+ (ER(+)PgR（+）和ER（+)PgR(-)）年龄特异性率随着年龄的增长而增加（但在50-54岁之后速度较慢），而ER- (ER- PgR（+）和ER（-)PgR(-)）年龄特异性率在50-54岁之后没有增加。不同的ER/PgR状态，不同种族/族裔群体的发病率排序不同。除了ER-和ER(-)PgR（-）癌症外，ER/PgR组的I期发病率高于II期发病率。ER+癌的2级（中分化）率高于3级和4级（低分化和未分化）率，但ER-癌的2级（中分化）率不高。这些结果提示，尽管乳腺癌是一种具有巨大异质性的疾病，但多种类型的乳腺癌可以通过其ER状态，甚至ER/PgR状态划分为不同的亚群，其癌症特征可能对理解乳腺癌的多重性具有重要意义。
It has been reported that age-specific breast cancer rates vary by estrogen receptor and progesterone receptor status. We report breast cancer rates for age-at-diagnosis, stage-at-diagnosis, histological grade and type by estrogen (ER) and progesterone (PgR) receptor status in six major racial/ethnic groups. The average annual age-adjusted rates for breast cancers with estrogen receptor positive (ER+), ER-, progesterone receptor positive (PgR(+)), PgR(-), ER(+)PgR(+), ER(+)PgR(-), ER(-)PgR(+) and ER(-)PgR(-) are determined from 123,732 breast cancers with known ER status, diagnosed from 1992 to 1998 from 11 Surveillance, Epidemiology, and End Results (SEER) cancer registries. For each racial/ethnic group, their ER+ (ER(+)PgR(+) and ER(+)PgR(-)) age-specific rates increased with age (but at a slower pace after ages 50-54) while their ER- (ER- PgR(+) and ER(-)PgR(-)) age-specific rates did not increase after ages 50-54. The rank orders of the rates among the racial/ethnic groups varied by ER/PgR status. The stage I rates were greater than the stage II rates for the ER/PgR groups except for ER- and ER(-)PgR(-) cancers. The grade 2 (moderately differentiated) rates were greater than the grades 3 and 4 (poorly differentiated and undifferentiated cancers) rates for ER+ cancers, but not for ER- cancers. These results suggest that although breast cancer is a disease with enormous heterogeneity, the multiple types of breast cancer can be separated into distinct subgroups by their ER status, and perhaps by their ER/PgR status, and their cancer characteristics may be important in understanding the multiple nature of breast cancer.