SELECTIVE BREEDING OF RATS DIFFERING IN SENSITIVITY TO THE EFFECTS OF ACUTE ETHANOL ADMINISTRATION
SELECTIVE BREEDING OF RATS DIFFERING IN SENSITIVITY TO THE EFFECTS OF ACUTE ETHANOL ADMINISTRATION
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DOI：
10.1111/j.1530-0277.1992.tb00634.x
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发表时间：
1992-02-01
影响因子：
3.2
通讯作者：
DEITRICH, RA
中科院分区：
文献类型：
--
作者：
DRASKI, LJ;SPUHLER, KP;DEITRICH, RA
正在用来自遗传异质性N/Nih储备的大鼠进行大鼠对乙醇麻醉作用敏感性的选择性育种。用重复的高（HAS）、低（LAS）和对照酒精敏感（CAS）系实现了13代家族内选择。在乙醇给药后觉醒时，睡眠时间和血液乙醇浓度（BEC）的线之间已经实现了显着的分离。总的来说，到目前为止获得的结果重复了短睡眠（SS）和长睡眠（LS）小鼠的发现。一个例外是，高酒精敏感性大鼠（HAS）也似乎对戊巴比妥相对于LAS大鼠更敏感。这一发现与SS和LS小鼠的结果相反，其中低乙醇敏感性SS小鼠似乎比LS小鼠对戊巴比妥更敏感。
Selective breeding of rats for sensitivity to the anesthetic effects of ethanol is being carried out with rats derived from the genetically heterogeneous N/Nih stock. Thirteen generations of within family selection have been achieved with replicate high (HAS), low (LAS) and control alcohol sensitive (CAS) lines. Significant separation between lines on sleep time and blood ethanol concentration (BEC) at awakening following ethanol administration has been achieved. in general, the results obtained so far replicate the findings with short (SS) and long (LS) sleep mice. One exception is that the high alcohol sensitivity rats (HAS) also appear more sensitive to pentobarbital relative to LAS rats. This finding is opposite to that which occurs with SS and LS mice where the low ethanol sensitive SS mice appear more sensitive to pentobarbital than the LS mice.