Phospholipid scrambling by rhodopsin.
Phospholipid scrambling by rhodopsin.
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DOI：
10.1039/c5pp00195a
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发表时间：
2015-11
期刊：
影响因子：
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通讯作者：
Menon AK
中科院分区：
文献类型：
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作者：
Ernst OP;Menon AK
视紫红质作为一种视觉色素和G蛋白偶联受体，在弱光视觉中起重要作用。我们最近发现，它也作为一个ATP-独立的磷脂scramblase：当重组成大的单层囊泡，视紫红质加速通常缓慢的跨双层转运常见的磷脂超过1000倍，速率超过10,000磷脂运输每视紫红质每秒。在这里，我们总结了导致这一发现的工作，并推测视紫红质扰乱磷脂的机制。我们还提出了一个假设，视紫红质的scramblase活性是必要的ABC转运蛋白ABCA 4的功能，负责减轻视网膜中的11-顺式-视网膜和bis-retinoids的毒性积累。视紫红质作为磷脂乱序酶的前景
Rhodopsin has been intensively characterized in its role as a visual pigment and G protein-coupled receptor responsible for dim-light vision. We recently discovered that it also functions as an ATP-independent phospholipid scramblase: when reconstituted into large unilamellar vesicles, rhodopsin accelerates the normally sluggish transbilayer translocation of common phospholipids by more than 1000-fold, to rates in excess of 10,000 phospholipids transported per rhodopsin per second. Here we summarize the work leading to this discovery and speculate on the mechanism by which rhodopsin scrambles phospholipids. We also present a hypothesis that rhodopsin’s scramblase activity is necessary for the function of the ABC transporter ABCA4 that is responsible for mitigating the toxic accumulation of 11-cis-retinal and bis-retinoids in the retina. Rhodopsin as phospholipid scramblase – A perspective