A Novel Neural Prediction Error Found in Anterior Cingulate Cortex Ensembles
A Novel Neural Prediction Error Found in Anterior Cingulate Cortex Ensembles
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DOI：
10.1016/j.neuron.2017.06.021
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发表时间：
2017-07-19
期刊：
影响因子：
16.2
通讯作者：
Seamans, Jeremy Keith
中科院分区：
文献类型：
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作者：
Hyman, James Michael;Holroyd, Clay Brian;Seamans, Jeremy Keith
前扣带回皮质(ACC)的功能仍然存在争议，但许多理论认为它在行为适应中发挥了作用，部分原因是每当预期被违反时，ACC上就会诱发一种强大的事件相关电位-反馈相关负波(FN)。我们从ACC记录了大鼠执行的任务与可靠地在人类身上唤起FN的任务相同。研究发现，一部分神经元将预期结果编码为抽象的结果表征。试验期间出现奖励/非奖励结果表征的程度取决于之前的结果历史。当系综从代表预期结果转移到实际结果时，在不一致的试验中产生了预测误差，同时我们先前在局部场势中报告了FN。这些结果描述了一种新的预测误差信号模式，该模式由ACC神经元发出，与FN的产生有关。
The function of the anterior cingulate cortex (ACC) remains controversial, yet many theories suggest a role in behavioral adaptation, partly because a robust event-related potential, the feedback-related negativity (FN), is evoked over the ACC whenever expectations are violated. We recorded from the ACC as rats performed a task identical to one that reliably evokes an FN in humans. A subset of neurons was found that encoded expected outcomes as abstract outcome representations. The degree to which a reward/non-reward outcome representation emerged during a trial depended on the history of outcomes that preceded it. A prediction error was generated on incongruent trials as the ensembles shifted from representing the expected to the actual outcome, at the same time point we have previously reported an FN in the local field potential. The results describe a novel mode of prediction error signaling by ACC neurons that is associated with the generation of an FN.