Hedgehog Signalling in the Embryonic Mouse Thymus.
Hedgehog Signalling in the Embryonic Mouse Thymus.
复制标题
DOI：
10.3390/jdb4030022
复制
发表时间：
2016-07-16
影响因子：
2.7
通讯作者：
Crompton T
中科院分区：
文献类型：
--
作者：
Barbarulo A;Lau CI;Mengrelis K;Ross S;Solanki A;Saldaña JI;Crompton T
T细胞在胸腺中发育，胸腺为T细胞命运特化和多能祖细胞分化为主要组织相容性复合体（MHC）限制性非自身反应性T细胞提供了必要的环境。在这里，我们回顾刺猬信号通路在T细胞发育，胸腺上皮细胞（TEC）的发展，和胸腺细胞TEC串扰在胚胎小鼠胸腺在妊娠的最后一周的作用。
T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation.