The biology of protein kinase C.
The biology of protein kinase C.
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DOI：
10.1007/978-94-007-2888-2_28
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发表时间：
2012
影响因子：
--
通讯作者：
Lily Zeng;S. Webster;P. M. Newton
中科院分区：
文献类型：
--
作者：
Lily Zeng;S. Webster;P. M. Newton
本文对最早发现的钙依赖蛋白激酶之一--蛋白激酶C的生物学进行了基本的介绍。我们回顾了蛋白激酶C的结构和功能，以及一些不同亚型的底物。然后，我们回顾了在实验系统中抑制PKC的策略，最后讨论了靶向PKC的治疗潜力。摘要介绍了每个方面，并在适当情况下提供了指向详细资源的链接。
This review gives a basic introduction to the biology of protein kinase C, one of the first calcium-dependent kinases to be discovered. We review the structure and function of protein kinase C, along with some of the substrates of individual isoforms. We then review strategies for inhibiting PKC in experimental systems and finally discuss the therapeutic potential of targeting PKC. Each aspect is covered in summary, with links to detailed resources where appropriate.