Monoclonal-Antibody-Templated Gold Nanoclusters for HER2 Receptors Targeted Fluorescence Imaging
Monoclonal-Antibody-Templated Gold Nanoclusters for HER2 Receptors Targeted Fluorescence Imaging
复制标题
用于 HER2 受体靶向荧光成像的单克隆抗体模板金纳米簇
DOI：
10.1021/acsabm.0c00905
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发表时间：
2020
影响因子：
4.7
通讯作者：
Fan Wang
中科院分区：
文献类型：
--
作者：
Xin Zhang;Muhua Chen;Yunwei Zhang;Yi Hou;Yue Wu;Meinan Yao;Liqiang Li;Linqing Shi;Tianyu Liu;Biao Hu;Huiyun Zhao;Xiaoda Li;Jiyun Shi;Bing Jia;Fan Wang
HER2 receptor-specific monoclonal-antibody-templated gold nanoclusters, Herceptin-templated Au NCs (Her-Au NCs), have been successfully obtained via “green” synthesis. This strategy allows the fluorescent gold nanoclusters (Au NCs) formed in the three-dimensional structure of Herceptin without destroying the high specificity and affinity to HER2 receptors. The Her-Au NCs have been found to be superior compared to Cy3-Herceptin in the fluorescence emission (λem= 645 nm) and the photostability under high-intensity UV irradiation or long-time storage. Moreover, Her-Au NCs can achieve receptor-specific imaging without targeted modification owing to the HER2-binding ability of the Herceptin scaffold. For imaging applications, Her-Au NCs can be utilized as effective optical probes for not only fluorescence imaging of HER2-positive cancer cells but also imaging of HER2-positive tumors in vivo.
