Value of MIB-1 labelling index (LI) in gliomas and its correlation with other prognostic factors. A clinicopathologic study.
Value of MIB-1 labelling index (LI) in gliomas and its correlation with other prognostic factors. A clinicopathologic study.
复制标题
MIB-1标记指数（LI）在胶质瘤中的价值及其与其他预后因素的相关性。
DOI：
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发表时间：
2000
影响因子：
1.9
通讯作者：
J. Forteza
中科院分区：
文献类型：
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作者：
C. Rodríguez;J. Suárez;M. Vázquez;M. Sobrido;M. Abraldes;F. Barros;J. Forteza
背景
近年来，单克隆抗体MIB-1已成为衡量胶质瘤增殖潜力的主要因素。该抗体相当于冷冻切片中使用的 Ki-67，并与通过细胞周期表达的核蛋白发生反应。我们研究了 MIB-1 标记指数 (LI) 作为神经胶质瘤独立预后因素的价值及其与临床和病理参数的关系。
方法
使用链霉亲和素-生物素复合物 (SBC) 免疫组织化学方法测定 139 例神经胶质瘤中的 MIB-1 LI。 MIB-1 LI 免疫反应性用自动细胞计数系统测量。通过使用 Kaplan-Meier 双变量分析和 Cox 多变量回归研究生存率。
结果
在双变量分析中，MIB-1 LI 随着年龄、组织学分级和幕上横向位置而增加。只有大小和肿瘤分级在 Cox 回归中具有重要意义。
结论
也许这种增殖标志物受到许多因素的影响，从而降低了其作为孤立预后参数的价值。
BACKGROUND
In recent years, the monoclonal antibody MIB-1 has become the main factor to measure the proliferative potential of glial tumors. This antibody is equivalent to Ki-67, which is used in frozen sections, and reacts with a nuclear protein that is expressed through the cell cycle. We have investigated the value of MIB-1 Labelling Index (LI) as an independent prognostic factor in gliomas and its relationship with clinical and pathological parameters.
METHODS
MIB-1 LI was determined in 139 gliomas by using the Streptavidin-Biotin Complex (SBC) immunohistochemical method. MIB-1 LI immunoreactivity was measured with an automatic cell counting system. Survival was studied by using the Kaplan-Meier bivariant analysis and Cox multivariant regression.
RESULTS
In bivariant analysis MIB-1 LI increased with age, histological grade and a supratentorial lateral location. Only size and tumor grade were significant in Cox regression.
CONCLUSIONS
Perhaps this proliferation marker is influenced by many factors which reduce its value as an isolated prognostic parameter.