The photodynamic activity and toxicity evaluation of 5,10,15-tris(ethoxylcarbonyl)corrole phosphorus(V) in vivo and in vitro
The photodynamic activity and toxicity evaluation of 5,10,15-tris(ethoxylcarbonyl)corrole phosphorus(V) in vivo and in vitro
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5,10,15-三(乙氧基羰基)咔咯磷(V)体内外光动力活性及毒性评价
DOI：
10.1016/j.ejmech.2018.12.031
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发表时间：
2019
影响因子：
6.7
通讯作者：
Zhang Hai-Tao
中科院分区：
文献类型：
--
作者：
Zhang Zhao;Yu Hua-Jun;Huang Hui;Wang Hua-Hua;Wu Shang;Liu Hai-Yang;Zhang Hai-Tao
开发新型、高效、无毒的光敏剂是光动力学治疗的一个挑战性课题。在我们以前的研究中，corrole已被证明是一个有前途的PS在PDT的癌细胞。本文合成了一种新型的缺电子平面型磷（乙氧羰基）咔咯（1-P），并对其结构进行了表征。用标准方法评价1-Pin HepG 2异种移植瘤的体外光动力学活性和毒性。结果表明，1-P是一种潜在的高效、低毒的PS，这表明该类可咯是一种很有前途的PDT抗肿瘤PS。此外，还通过凋亡抗体阵列、免疫组化和蛋白质印迹（WB）实验对1-P的潜在抗肿瘤机制进行了研究，发现1-P的PDT活性可以降解SIRT 1（一种重要的脱乙酰酶），激活Fas信号通路，从而抑制肝癌细胞的生长。
The development of novel, efficient and nontoxic photosensitizers (PSs) is a challenging task for photodynamic therapy (PDT). In our previous study, corrole had been demonstrated to be a promising PS in PDT for cancer cells. In this paper, a novel electron-deficient flat phosphorustris(ethoxycarbonyl) corrole (1-P) was synthesized and characterized. Invitrophotodynamic activities and toxicity of1-Pin HepG2 xenograft tumours was evaluated by standard assay. The results shown1-Pdisplayed a potential efficient and low-toxic PS, which suggesting this kind of corrole is a powerful and promising antitumor PS for PDT. In addition, the potential anti-tumour mechanism study of1-Pwas also investigated by the apoptosis antibody array, immunohistochemical and western blotting assay (WB) experiments, we found that the PDT activity of1-Pcan degrade SIRT1 (an important deacetylase), and activate the Fas signal pathway to inhibit the growth of liver cancer cells.