A systematic scoping review of the genetic ancestry of the Brazilian population
A systematic scoping review of the genetic ancestry of the Brazilian population
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DOI：
10.1590/1678-4685-gmb-2018-0076
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发表时间：
2019-09-01
影响因子：
2.1
通讯作者：
Brito, Cristiana Ferreira Alves de
中科院分区：
文献类型：
--
作者：
Souza, Aracele Maria de;Resende, Sarah Stela;Brito, Cristiana Ferreira Alves de
巴西人口的遗传背景主要由三个亲本群体组成：欧洲人、非洲人和美洲原住民。本研究的目的是概述巴西不同地理区域的遗传祖先估计，并分析这些估计所涉及的因素。在本系统范围审查中，纳入了51项研究，涵盖了巴西5个地区19个州的81个人群。为了减少不同采样方法研究的潜在偏倚，我们计算了由个体数量加权的平均遗传祖先。欧洲、非洲和美洲原住民血统的加权平均比例分别为68.1%、19.6%和11.6%。在区域一级，欧洲人的贡献最大的是南方，非洲人和美洲土著人的贡献最大的分别是东北和北方地区。在东北地区的各州中，巴伊亚和塞阿拉表现出显著差异，表明不同的人口历史。这篇评论有助于更广泛地了解巴西血统，并指出血统估计的影响类型的分子标记和采样方法。
The genetic background of the Brazilian population is mainly characterized by three parental populations: European, African, and Native American. The aim of this study was to overview the genetic ancestry estimates for different Brazilian geographic regions and analyze factors involved in these estimates. In this systematic scoping review were included 51 studies, comprehending 81 populations of 19 states from five regions of Brazil. To reduce the potential of bias from studies with different sampling methods, we calculated the mean genetic ancestry weighted by the number of individuals. The weighted mean proportions of European, African, and Native American ancestries were 68.1%, 19.6%, and 11.6%, respectively. At the regional level, the highest European contribution occurred in the South, while the highest African and Native American contributions occurred in the Northeastern and Northern regions, respectively. Among states in the Northeast region, Bahia and Ceara showed significant differences, suggesting distinct demographic histories. This review contributes for a broader understanding of the Brazilian ancestry and indicates that the ancestry estimates are influenced by the type of molecular marker and the sampling method.