Single-molecule bioelectronics.
Single-molecule bioelectronics.
复制标题
单分子生物电子学。
DOI：
10.1002/wnan.1323
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Shepard,KennethL
中科院分区：
文献类型：
--
作者：
Rosenstein,JacobK;Lemay,SergeG;Shepard,KennethL
Experimental techniques that interface single biomolecules directly with microelectronic systems are increasingly being used in a wide range of powerful applications, from fundamental studies of biomolecules to ultra‐sensitive assays. In this study, we review several technologies that can perform electronic measurements of single molecules in solution: ion channels, nanopore sensors, carbon nanotube field‐effect transistors, electron tunneling gaps, and redox cycling. We discuss the shared features among these techniques that enable them to resolve individual molecules, and discuss their limitations. Recordings from each of these methods all rely on similar electronic instrumentation, and we discuss the relevant circuit implementations and potential for scaling these single‐molecule bioelectronic interfaces to high‐throughput arrayed sensing platforms.WIREs Nanomed Nanobiotechnol2015, 7:475–493. doi: 10.1002/wnan.1323This article is categorized under:Diagnostic Tools > Biosensing
