Hypoxia inducible factor 1α in hepatocellular carcinoma with cirrhosis: Association with prognosis
Hypoxia inducible factor 1α in hepatocellular carcinoma with cirrhosis: Association with prognosis
复制标题
肝硬化肝细胞癌缺氧诱导因子 1α：与预后的关系
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Li Zhu
中科院分区：
文献类型：
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作者：
Dan Wang;Xiaojing Zhang;Yapeng Lu;Xueting Wang;Li Zhu
背景：缺氧诱导因子1α（HIF-1α）是一种与许多肿瘤的癌变和转移相关的蛋白质。然而，关于 HIF-1α 对肝硬化肝细胞癌 (HCC) 患者的预后价值知之甚少。方法：收集 HCC (n = 419) 和慢性肝炎 (n = 49) 患者的临床病理信息和随访数据。根据免疫组织化学染色的百分比对 HIF-1α 表达进行评分。通过卡方检验评估HIF-1α表达与临床特征之间的相关性。并采用多因素Cox回归分析进行生存分析。结果：肝硬化患者中，HCC中HIF-1α阳性表达频率高于慢性肝炎（P=0.002）。 HIF-1α阳性表达与肝硬化HCC血管侵犯(P=0.002)、TNM分期(P=0.005)、HBV感染(P=0.005)、肿瘤大小(P=0.025)和门静脉癌栓(P=0.001)显着相关。而在无肝硬化患者中，HIF-1α阳性表达与血管侵犯（P = 0.039）和AFP值（P = 0.001）显着相关。与HIF-1α“阴性”患者相比，HIF-1α“阳性”患者的总生存率降低，这是肝硬化HCC患者的独立不良预后因素（多变量分析P = 0.001），但对于肝硬化HCC患者则不然。 无肝硬化患者..
Background.Hypoxia inducible factor 1α (HIF-1α) is a protein related with carcinogenesis and metastasis in many tumors. However, little is known about the prognostic value of HIF-1α in hepatocellular carcinoma (HCC) patients with cirrhosis..Methods.Clinical-pathological information and follow-up data were collected from HCC (n = 419) and chronic hepatitis (n = 49) patients. HIF-1α expression was scored based on the percentage of immunohistochemical staining. Correlations between HIF-1α expression and clinical features were evaluated by Chi-square test. And survival analysis was performed by multivariate Cox regression analysis..Results.In cirrhosis patients, the frequency of HIF-1α positive expression in HCC was higher than in chronic hepatitis (P = 0.002). HIF-1α positive expression was significantly associated with vascular invasion (P = 0.002), TNM stage (P = 0.005), HBV infection (P = 0.005), tumor size (P = 0.025) and portal vein tumor thrombus (P = 0.001) in HCC with liver cirrhosis. While, in cirrhosis-free patients, HIF-1α positive expression had a significant correlation with vascular invasion (P = 0.039) and AFP value (P = 0.001) in. HIF-1α “positive” had decreased overall survival compared to HIF-1α “negative” patients and this was an independent adverse prognostic factor (multivariable analysis P = 0.001) for HCC patients with cirrhosis, but not for cirrhosis-free patients..