ALTERED MYOCARDIAL HIGH-ENERGY PHOSPHATE METABOLITES IN PATIENTS WITH DILATED CARDIOMYOPATHY
ALTERED MYOCARDIAL HIGH-ENERGY PHOSPHATE METABOLITES IN PATIENTS WITH DILATED CARDIOMYOPATHY
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DOI：
10.1016/0002-8703(91)90527-o
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发表时间：
1991-09-01
影响因子：
4.8
通讯作者：
GERSTENBLITH, G
中科院分区：
文献类型：
--
作者：
HARDY, CJ;WEISS, RG;GERSTENBLITH, G
对20名扩张型心肌病（DCM）患者和12名正常志愿者进行一维相位编码p -31核磁共振（NMR）波谱研究，并结合H-1成像，静息时评估缺血性或特发性扩张型心肌病（DCM）患者的心肌高能磷酸盐代谢。校正了部分饱和和血液代谢物对光谱的污染后，前心肌磷酸肌酸/ β -三磷酸腺苷（PCr/ β - atp）的测量值在正常志愿者中平均为1.80 +/- 0.06（平均+/- SE），在患者中平均为1.46 +/- 0.07，显著降低（p < 0.001）。DCM合并冠状动脉疾病患者（n = 9） PCr/ β - atp比值平均为1.53 +/- 0.07，单独DCM患者为1.41 +/- 0.12 (n = 11)，两者差异无统计学意义。心肌PCr/ATP比值与左室射血分数无显著相关（r = 0.34）。这些研究表明，在人类缺血性和特发性扩张型心肌病中，心肌PCr/ATP比值在静止状态下降低。
Myocardial high-energy phosphate metabolism in patients with dilated cardiomyopathy (DCM) of ischemic or idiopathic etiology was assessed at rest by one-dimensional phase-encoded P-31-nuclear magnetic resonance (NMR) spectroscopy studies performed in conjunction with H-1 imaging in 20 patients with DCM and in 12 normal volunteers. The measured values of anterior myocardial phosphocreatine/beta-adenosine triphosphate (PCr/beta-ATP), corrected for partial saturation and contamination of the spectra by blood metabolites, averaged 1.80 +/- 0.06 (mean +/- SE) in normal volunteers and 1.46 +/- 0.07 in the patients overall, a highly significant (p < 0.001) decrease. In patients with DCM accompanied by coronary artery disease (n = 9), the PCr/beta-ATP ratio averaged 1.53 +/- 0.07, while in those with DCM alone it was 1.41 +/- 0.12 (n = 11), a value that was not significantly different. There was no significant correlation (r = 0.34) between myocardial PCr/ATP ratio and left ventricular ejection fraction in patients. These studies demonstrate that myocardial PCr/ATP ratios are reduced at rest in human ischemic and idiopathic dilated cardiomyopathy.