Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change.
Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change.
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DOI：
10.1016/j.cub.2018.08.047
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发表时间：
2018-11-05
期刊：
影响因子：
--
通讯作者：
Courtier-Orgogozo V
中科院分区：
文献类型：
--
作者：
Nagy O;Nuez I;Savisaar R;Peluffo AE;Yassin A;Lang M;Stern DL;Matute DR;David JR;Courtier-Orgogozo V
不同的性状常常在物种之间存在共变。由于在核苷酸水平上剖析的案例相对较少，因此很少研究单个突变可能导致物种间多个特征进化的可能性。桑托梅果蝇在腿上进化出了额外的性梳感觉齿，并且在生殖器上失去了两根感觉刚毛。我们提供的证据表明，scute 基因增强子中的单核苷酸取代导致了这两种变化。该突变改变了发育中生殖器中Hox蛋白Abdominal-B的结合位点，导致鬃毛损失，并改变了发育中腿部中的另一个因子，导致鬃毛增加。我们的研究表明，物种之间的形态进化可以通过影响几种性二态性状的单核苷酸变化来发生。纳吉等人。在果蝇物种之间鉴定出一种位于基因调控区域的核苷酸取代，该取代有助于两个不同的交配器官的进化变化。
Diverse traits often covary between species. The possibility that a single mutation could contribute to the evolution of several characters between species is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophila santomea has evolved additional sex comb sensory teeth on its legs and has lost two sensory bristles on its genitalia. We present evidence that a single nucleotide substitution in an enhancer of the scute gene contributes to both changes. The mutation alters a binding site for the Hox protein Abdominal-B in the developing genitalia, leading to bristle loss, and for another factor in the developing leg, leading to bristle gain. Our study suggests that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits. Nagy et al. identify between Drosophila species one nucleotide substitution that lies in a gene-regulatory region and that contributes to evolutionary change of two distinct copulatory organs.
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