Paper Capillary Enables Effective Sampling for Microfluidic Paper Analytical Devices
Paper Capillary Enables Effective Sampling for Microfluidic Paper Analytical Devices
复制标题
纸毛细管可实现微流体纸分析设备的有效采样
DOI：
10.1021/acssensors.8b00335
复制
发表时间：
2018-07-01
期刊：
影响因子：
8.9
通讯作者：
Chen, Hong-Yuan
中科院分区：
文献类型：
--
作者：
Shangguan, Jin-Wen;Liu, Yu;Chen, Hong-Yuan
引入纸毛细管以实现在微流体纸分析装置上的有效采样。通过耦合纸毛细管的宏观尺度毛细力和天然纸的微观尺度毛细力，可以利用适当的设计灵活地定制流体输送。随后，提出了一种混合流体模式的纸毛细管装置，该装置能够以阵列形式快速可靠地采样，具有较少的表面吸附和对不同组分的偏差。因此，所得到的设备支持高通量，定量和可重复的测定，通过手动操作。该平台实现了离子、蛋白质和微生物的多重分析，为μ PAD的更高层次分析奠定了基础。
The paper capillary is introduced to enable effective sampling on microfluidic paper analytical devices. By coupling the macroscale capillary force of paper capillary and the microscale capillary forces of native paper, fluid transport can be flexibly tailored with proper design. Subsequently, a hybrid-fluid-mode paper capillary device was proposed which enables fast and reliable sampling in an arrayed form with less surface adsorption and bias for different components. The resulting device thus supports high-throughput, quantitative, and repeatable assays by manual operation. With all these merits, multiplex analysis of ions, proteins, and microbes have all been realized on this platform, which has paved the way to higher analysis on mu PADs.