Influence of Regional Iron on the Motor Impairments of Parkinson's Disease: A Quantitative Susceptibility Mapping Study
Influence of Regional Iron on the Motor Impairments of Parkinson's Disease: A Quantitative Susceptibility Mapping Study
复制标题
局部铁对帕金森病运动障碍的影响：定量易感性绘图研究。
DOI：
10.1002/jmri.25434
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发表时间：
2017-05-01
影响因子：
4.4
通讯作者：
Zhang, Minming
中科院分区：
文献类型：
--
作者：
Guan, Xiaojun;Xuan, Min;Zhang, Minming
目的：由于纹状体-丘脑-皮质和小脑-丘脑-皮质回路在帕金森病（PD）异质性运动障碍中的作用逐渐被认识，本研究旨在探讨这些回路中皮质下主要核团的局部铁与不同运动障碍的关系。材料与方法：62例PD患者和40例正常人接受增强T2星星加权血管造影扫描（3.0 T）。根据帕金森病统一评定量表将患者分为震颤显性组（PD-TD）和运动不能/僵硬显性组（PD-AR）。测量了这些基数核磁化率的组间差异。结果：与对照组相比，PD-TD组和PD-AR组黑质磁化率均显著升高（P < 0.001; P <0.001）。PD-TD患者齿状核（DN）和红核（RN）的磁化率明显高于对照组（P < 0.001和P =0.004）。这些区域的磁化率也与震颤严重程度显著相关（对于DN，r = 0.444，P 0.001;对于RN，r=0.418，P=0.001）。结论：黑质铁蓄积是PD的共同特征，DN和RN的铁蓄积与震颤症状相关。我们的数据还表明，尾状核铁含量可能是一个潜在的标记运动不能/刚性进展。
Purpose: Because the roles of striatal-thalamo-cortical and cerebello-thalamo-cortical circuits in the heterogeneous motor impairments of Parkinson's disease (PD) are becoming recognized, this study was designed to investigate the relationships between regional iron in the cardinal subcortical nuclei in these circuits and the different motor impairments.Materials and Methods: Sixty-two PD patients and 40 normal subjects were included and accepted for Enhanced T2 Star Weighted Angiography Scanning (3.0T). According to the Unified Parkinson's Disease Rating Scale, patients were divided into tremor-dominant (PD-TD) and akinetic/rigid-dominant groups (PD-AR). The intergroup differences of magnetic susceptibility in those cardinal nuclei were measured. Correlation analyses between magnetic susceptibility and motor impairments were performed in all patients.Results: Nigral magnetic susceptibility significantly increased for each PD group compared with controls (P < 0.001 for PD-TD; P 0.001 for PD-AR). Magnetic susceptibility in the dentate nucleus (DN) and red nucleus (RN) for the PD-TD patients were significantly increased compared with controls (P < 0.001 and P =0.004, respectively). Magnetic susceptibility in these regions was also significantly correlated with tremor severity (r 0.444, P 0.001 for DN; r=0.418, P=0.001 for RN). Significant correlation between caudate magnetic susceptibility and akinetic/rigid severity were observed (r =0.322, P =0.015).Conclusion: This study provides evidence that nigral iron accumulation is a common characteristic in PD, while iron accumulation in the DN and RN is correlated with tremor symptoms. Our data also indicate that caudate iron content may be a potential marker for akinetic/rigid progression.