A high-resolution single nucleotide polymorphism genetic map of the mouse genome.
A high-resolution single nucleotide polymorphism genetic map of the mouse genome.
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DOI：
10.1371/journal.pbio.0040395
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发表时间：
2006-11
期刊：
影响因子：
9.8
通讯作者：
Flint J
中科院分区：
文献类型：
--
作者：
Shifman S;Bell JT;Copley RR;Taylor MS;Williams RW;Mott R;Flint J
高分辨率的遗传图谱是绘制复杂性状和研究重组所必需的。我们报告了迄今为止为除人类以外的任何生物创造的密度最高的基因图谱。利用均匀分布在小鼠基因组中的超过10,000个单核苷酸多态性，我们构建了近亲繁殖和近亲繁殖小鼠的遗传图谱，并分别为雄性和雌性构建了遗传图谱。重组率在远交系和近交系小鼠中高度相关，但在雄性和雌性之间的相关性相对较低。男性和女性重组图谱之间的差异以及与重组相关的序列特征与在人类中观察到的惊人相似。遗传图谱可从http://gscan.well.ox.ac.uk/#genetic_map获得，并作为本出版物的支持信息。基于雄性和雌性分离的远交系和近交系小鼠的高密度SNP图谱表明，小鼠和人类重组之间具有高度的同源性。
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, we have constructed genetic maps for both outbred and inbred mice, and separately for males and females. Recombination rates are highly correlated in outbred and inbred mice, but show relatively low correlation between males and females. Differences between male and female recombination maps and the sequence features associated with recombination are strikingly similar to those observed in humans. Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication. A high-density SNP map based on outbred and inbred mice with male and female separation suggests a high degree of homology between mouse and human recombination.
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