Pharmacokinetics of caffeine and its demethylated metabolites in lactation: predictions of milk to serum concentration ratios.
Pharmacokinetics of caffeine and its demethylated metabolites in lactation: predictions of milk to serum concentration ratios.
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哺乳期咖啡因及其去甲基化代谢物的药代动力学：牛奶与血清浓度比的预测。
DOI：
10.1023/a:1016207832591
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发表时间：
1995
影响因子：
3.7
通讯作者：
McNamara,PJ
中科院分区：
文献类型：
--
作者：
Oo,CY;Burgio,DE;Kuhn,RC;Desai,N;McNamara,PJ
本研究的目的是检验先前提出的扩散模型的能力[Fleishaker， J. C.et al. (1987)Journal of Pharmaceutical sciences, 76189-193]，通过体外测定咖啡因及其3种单去甲基化代谢物来预测人类志愿者的牛奶：血清浓度比。
The purpose of this study is to examine the ability of a diffusion model previously proposed [Fleishaker, J. C.et al. (1987)Journal of Pharmaceutical Sciences76189-193], to predict milk:serum concentration ratios fromin vitrodeterminations for caffeine and its 3 monodemethylated metabolites in human volunteers.