Epidemiology and risk factors of chronic kidney disease in India - results from the SEEK (Screening and Early Evaluation of Kidney Disease) study.
Epidemiology and risk factors of chronic kidney disease in India - results from the SEEK (Screening and Early Evaluation of Kidney Disease) study.
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DOI：
10.1186/1471-2369-14-114
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发表时间：
2013-05-28
期刊：
影响因子：
2.3
通讯作者：
Rajapurkar MM
中科院分区：
文献类型：
--
作者：
Singh AK;Farag YM;Mittal BV;Subramanian KK;Reddy SR;Acharya VN;Almeida AF;Channakeshavamurthy A;Ballal HS;P G;Issacs R;Jasuja S;Kirpalani AL;Kher V;Modi GK;Nainan G;Prakash J;Rana DS;Sreedhara R;Sinha DK;V SB;Sunder S;Sharma RK;Seetharam S;Raju TR;Rajapurkar MM
慢性肾脏疾病的发病率正在上升，这可能会在未来几年对医疗保健和经济构成重大问题。在印度，最近估计ESRD的年龄调整发病率为每百万人口229例（pmp），每年有> 100，000名新患者进入肾脏替代计划。我们对来自印度各地13个学术和私人医疗中心的6120名印度受试者进行了横断面筛选。我们通过专门设计的调查问卷获得个人和病史数据。采集血液和尿液样本。本分析中纳入的总队列为5588例受试者。所有参与者的平均± SD年龄为45.22 ± 15.2岁（范围18-98岁），其中55.1%为男性，44.9%为女性。SEEK-India队列中CKD的总体患病率为17.2%，平均eGFR为84.27 ± 76.46，而非CKD组为116.94 ± 44.65 mL/min/1.73 m2，而CKD组中79.5%的患者有蛋白尿。CKD 1、2、3、4和5期的患病率分别为7%、4.3%、4.3%、0.8%和0.8%。CKD的患病率为17.2%，约6%的患者患有CKD 3期或更严重。CKD风险因素与早期研究中报告的相似。应强调所有初级保健医生照顾高血压和糖尿病患者筛查早期肾损害。早期干预可以延缓肾脏疾病的进展。在印度，制定预防性卫生政策和分配更多资源用于治疗CKD/ESRD患者势在必行。
There is a rising incidence of chronic kidney disease that is likely to pose major problems for both healthcare and the economy in future years. In India, it has been recently estimated that the age-adjusted incidence rate of ESRD to be 229 per million population (pmp), and >100,000 new patients enter renal replacement programs annually. We cross-sectionally screened 6120 Indian subjects from 13 academic and private medical centers all over India. We obtained personal and medical history data through a specifically designed questionnaire. Blood and urine samples were collected. The total cohort included in this analysis is 5588 subjects. The mean ± SD age of all participants was 45.22 ± 15.2 years (range 18–98 years) and 55.1% of them were males and 44.9% were females. The overall prevalence of CKD in the SEEK-India cohort was 17.2% with a mean eGFR of 84.27 ± 76.46 versus 116.94 ± 44.65 mL/min/1.73 m2 in non-CKD group while 79.5% in the CKD group had proteinuria. Prevalence of CKD stages 1, 2, 3, 4 and 5 was 7%, 4.3%, 4.3%, 0.8% and 0.8%, respectively. The prevalence of CKD was observed to be 17.2% with ~6% have CKD stage 3 or worse. CKD risk factors were similar to those reported in earlier studies. It should be stressed to all primary care physicians taking care of hypertensive and diabetic patients to screen for early kidney damage. Early intervention may retard the progression of kidney disease. Planning for the preventive health policies and allocation of more resources for the treatment of CKD/ESRD patients are imperative in India.