Reading words and other people: A comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia.
Reading words and other people: A comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia.
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DOI：
10.1016/j.cortex.2016.05.014
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Gorno-Tempini ML
中科院分区：
文献类型：
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作者：
Binney RJ;Henry ML;Babiak M;Pressman PS;Santos-Santos MA;Narvid J;Mandelli ML;Strain PJ;Miller BL;Rankin KP;Rosen HJ;Gorno-Tempini ML
语义变异型原发性进行性失语症（svPPA）通常表现为以左侧半球为主的颞叶前部萎缩，且在语言领域的症状最为显著。较少见的情况是，患者表现为以右侧半球为主的颞叶萎缩，并伴有对名人面孔和情绪处理的明显障碍。很少有研究在这两个领域对这些患者群体进行客观比较，因此不清楚这些综合征在多大程度上重叠。通过影像学检查，将临床诊断为svPPA的患者分为左侧（n = 21）或右侧占优势（n = 12）两组，并与14名健康对照者进行比较。在语言方面，我们主要关注svPPA的两个标志性特征：物体命名和表层阅读障碍。两组都表现出命名缺陷和表层阅读障碍，不过左侧优势组的障碍更为严重。右侧优势组在对名人面孔的熟悉度判断和情感处理方面受损更为严重。我们的研究结果表明，这两种综合征有明显重叠，但处于连续统两端的早期病例对当前的临床标准构成了挑战。相关的神经影像学分析表明，左侧颞叶外侧中部与特殊单词阅读障碍有关，这与该区域是语音和语义知识之间的接口这一观点相符。
Semantic variant primary progressive aphasia (svPPA) typically presents with left-hemisphere predominant rostral temporal lobe atrophy and the most significant complaints within the language domain. Less frequently, patients present with right-hemisphere predominant temporal atrophy coupled with marked impairments in processing of famous faces and emotions. Few studies have objectively compared these patient groups in both domains and therefore it is unclear to what extent the syndromes overlap. Clinically diagnosed svPPA patients were characterized as left- (n= 21) or right-predominant (n = 12) using imaging and compared along with 14 healthy controls. Regarding language, our primary focus was upon two hallmark features of svPPA; confrontation naming and surface dyslexia. Both groups exhibited naming deficits and surface dyslexia although the impairments were more severe in the left-predominant group. Familiarity judgments on famous faces and affect processing were more profoundly impaired in the right-predominant group. Our findings suggest that the two syndromes overlap significantly but that early cases at the tail ends of the continuum constitute a challenge for current clinical criteria. Correlational neuroimaging analyses implicated a mid portion of the left lateral temporal lobe in exception word reading impairments in line with proposals that this region is an interface between phonology and semantic knowledge.