Adiponectin and type 2 diabetes in Samoan adults.
Adiponectin and type 2 diabetes in Samoan adults.
复制标题
萨摩亚成年人的脂联素和 2 型糖尿病。
DOI：
10.1002/ajhb.20858
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
McGarvey,StephenT
中科院分区：
文献类型：
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作者：
Dibello,JuliaR;Baylin,Ana;Viali,Satupaitea;Tuitele,John;Bausserman,Linda;McGarvey,StephenT
ObjectivePrevious studies have established an association between adiponectin and type 2 diabetes. It is unclear whether adiponectin will be useful among Samoan Islanders, characterized by markedly elevated levels of obesity, in differentiating those at risk of developing type 2 diabetes.MethodsCross‐sectional, genetic epidemiology study of obesity in American Samoa and Samoa 2002–2003 (n= 1,599). Logistic regression provided adjusted odds ratios and 95% confidence intervals for the association between adiponectin, diabetes, and prediabetes (impaired fasting glucose).ResultsThere is a significant decreasing trend in the odds of diabetes and prediabetes across increasing quintiles of adiponectin with an OR of 2.8 (95% CI: 1.6, 5.0) and 2.9 (95% CI: 1.5, 5.7), respectively, in the lowest relative to the highest quintile of adiponectin (P‐for‐trend = 0.004 and 0.001).ConclusionsAdiponectin is an important correlate, independent of other risk factors, of the pathogenesis of type 2 diabetes among Samoan islanders and may help distinguish those at higher risk of developing this disease. Am. J. Hum. Biol. 2009. © 2008 Wiley‐Liss, Inc.
