Update on enterovirus 71 infection
Update on enterovirus 71 infection
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DOI：
10.1016/j.coviro.2014.03.007
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发表时间：
2014-04-01
影响因子：
5.9
通讯作者：
Shih, Shin-Ru
中科院分区：
文献类型：
--
作者：
Huang, Peng-Nien;Shih, Shin-Ru
人类肠道病毒71型（EV71）已成为全球儿童病毒性脑炎的主要病因。EV71受体的鉴定为了解EV71的复制和组织嗜性提供了有用的信息。宿主因子与EV71的内部核糖体进入位点（IRES）相互作用以调节病毒翻译。然而，决定EV71毒力的基因组的特定分子特征仍不清楚。EV 71衣壳蛋白VP 1区域可能有助于毒力和向神经性。表达EV71受体的转基因小鼠感染该病毒后，表现出与在受感染的人类中观察到的类似的疾病。目前迫切需要开发抗病毒药物和疫苗来预防EV71的流行。描述病毒宿主相互作用和确定可能控制EV71致病机制的神经嗜性的特定机制将是实质性的进展。
Human enterovirus type 71 (EV71) has emerged as a major cause of viral encephalitis in children worldwide. The identified EV71 receptors provide useful information for understanding EV71replication and tissue tropism. Host factors interact with the internal ribosome entry site (IRES) of EV71 to regulate viral translation. However, the specific molecular features of the EV71 genome that determine virulence remain unclear. The EV71 capsid protein VP1 region might contribute to virulence and neurotropism. Transgenic mice expressing the EV71 receptor that were infected with the virus exhibited a disease similar to that observed in infected humans. Antiviral drug and vaccine development is urgently required to prevent EV71 epidemics. Delineating viral host interactions and identifying specific mechanisms that might control the neural tropism of EV71 pathogenesis would be substantial advances.