Blood pressure, body composition, and fat tissue cellularity in adults.
Blood pressure, body composition, and fat tissue cellularity in adults.
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成人的血压、身体成分和脂肪组织细胞结构。
DOI：
10.1161/01.hyp.4.3.382
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Knittle,JL
中科院分区：
文献类型：
--
作者：
Siervogel,RM;Roche,AF;Chumlea,WC;Morris,JG;Webb,P;Knittle,JL
虽然多年来人们已经认识到总体体重与血压之间存在强烈的正相关关系，但目前尚不清楚总体体重本身是否在这种联系中起重要作用，或者总体体重的某个组成部分，如瘦体重或总体脂肪，是否对这种关系起作用。为了确定这些成分的相对重要性，217名18至49岁（X +/- sd = 33.1 +/- 8.9岁）的未选择血压或身体成分的健康成年人通过水下称重测量了身体密度。体密度用于估计体脂百分比，由此确定瘦体重和总体重。此外，从臀区进行脂肪组织活检，并使用四氧化锇法测量平均脂肪细胞大小；然后估计脂肪细胞数量。在男性和女性中，在调整年龄后，血压（收缩压、舒张压和平均动脉压）与体脂百分比、体脂总量或脂肪细胞数量之间存在高度显著的正偏相关（r = 0.2至0.3）。瘦体重或脂肪细胞大小与血压之间没有明显的相关性。这些发现表明，脂肪量而不是体重本身，可能是成人血压升高的一个重要病因。
While total body mass has been recognized for many years as having a strong positive association with blood pressure, it is not known whether body mass per se is important in this association or if a component of total mass, such as lean body mass or total body fat, is responsible for the relationship. To determine the relative importance of these components, 217 healthy adults unselected with respect to blood pressure or body composition, who were 18 to 49 years of age (X +/- sd = 33.1 +/- 8.9 years) had body density measured by underwater weighing. Body density was used to estimate percent body fat from which lean body mass and total body fat mass were determined. In addition, an adipose tissue biopsy from the gluteal area was made, and average fat cell size was measured using the osmium tetroxide method; fat cell number was then estimated. In both males and females, after adjusting for age, there were highly significant, positive partial correlations (r = 0.2 to 0.3) between measures of blood pressure (systolic, diastolic, and mean arterial) and percent body fat, total body fat mass or fat cell number. No significant correlation existed between lean body mass or fat cell size and any measure of blood pressure. These findings suggest that fat mass as opposed to body mass, per se, may be an important etiological component in elevated blood pressure in adults.