Continuous synthesis of amorphous carbonated apatites.
Continuous synthesis of amorphous carbonated apatites.
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DOI：
10.1016/s0142-9612(01)00390-8
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发表时间：
2002-06
期刊：
影响因子：
14
通讯作者：
D. Tadić;Fabian Peters;Matthias Epple
中科院分区：
文献类型：
--
作者：
D. Tadić;Fabian Peters;Matthias Epple
采用计算机控制的连续反应器，通过水溶液的快速混合制备非晶碳酸化羟基磷灰石。通过调节初始溶液中磷酸盐与碳酸盐的比例，可以改变固体产物中碳酸盐的含量。控制和监测主要反应参数（温度、pH值、搅拌器速度、溶液组成和过饱和度）。通过控制这些工艺参数，可以可重复地制备具有微调结晶度、形态和碳酸盐含量的非化学计量的羟基磷灰石。在恒定pH（4.4）下体外测试了在骨吸收条件下的较高溶解度。
Amorphous carbonated hydroxyapatite was prepared by rapid mixing of aqueous solutions of a continuous computer-controlled reactor. The variation of the carbonate content in the solid product is possible by adjustment of the ratios of phosphate to carbonate in the initial solution. The principal reaction parameters (temperature, pH, stirrer speed, solution composition and supersaturation) are controlled and monitored. By controlling these processing parameters, a non-stoichiometric hydroxyapatite with fine-tuned crystallinity, morphology, and carbonate content can be reproducibly prepared. The higher solubility under the conditions of osteoclastic resorption was tested in vitro at constant pH (4.4).