The effects of low-intensity narrow-band blue-light treatment compared to bright white-light treatment in seasonal affective disorder
The effects of low-intensity narrow-band blue-light treatment compared to bright white-light treatment in seasonal affective disorder
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DOI：
10.1016/j.jad.2018.01.024
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发表时间：
2018-05-01
影响因子：
6.6
通讯作者：
Hommes, Vanja
中科院分区：
文献类型：
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作者：
Meesters, Ybe;Duijzer, Wianne B.;Hommes, Vanja
背景资料：自从发现了一种对470-490 nm蓝光具有最高敏感性的新感光体以来，人们就推测蓝光在治疗季节性情感障碍（SAD）方面比传统治疗方法具有一些优势。在这项研究中，我们比较了暴露于窄带蓝光（BLUE）和宽波长白色光（BLT）治疗SAD的效果。在15天的设计中，45名SAD患者连续5天完成30分钟的光治疗，21名受试者接受白光治疗24例受试者接受窄谱蓝光（BLUE，100 lx，辐照度1.0 W/m2）照射。所有参与者每周完成一次关于情绪和能量水平的问卷调查，并通过SIGH-SAD进行评估，这是主要的结果测量。（BLT 73.2%，效应量3.37; BLUE 67%，效应量2.63），两种情况之间的结果没有统计学显著差异。结论：光治疗是SAD的有效治疗方法。使用窄带蓝光与使用明亮白光的治疗同样有效。
Background: Ever since a new photoreceptor was discovered with a highest sensitivity to 470-490 nm blue light, it has been speculated that blue light has some advantages in the treatment of Seasonal Affective Disorder (SAD) over more traditional treatments. In this study we compared the effects of exposure to narrow-band blue light (BLUE) to those of broad-wavelength white light (BLT) in the treatment of SAD.Methods: In a 15-day design, 45 patients suffering from SAD completed 30-min sessions of light treatment on 5 consecutive days.21 subjects received white-light treatment (BLT, broad-wavelength without UV, 10 000 lx, irradiance 31.7 W/m(2)), 24 subjects received narrow-band blue light (BLUE, 100 lx, irradiance 1.0 W/m(2)). All participants completed weekly questionnaires concerning mood and energy levels, and were also assessed by means of the SIGH-SAD, which is the primary outcome measure.Results: On day 15, SIGH-SAD ratings were significantly lower than on day 1 (BLT 73.2%, effect size 3.37; BLUE 67%, effect size 2.63), which outcomes were not statistically significant different between both conditions.Limitations: Small sample size.Conclusions: Light treatment is an effective treatment for SAD. The use of narrow-band blue light is equally effective as a treatment using bright white-light.