LATERAL DISTRIBUTION OF HYPOTHALAMIC SIGNALS CONTROLLING THERMOREGULATORY VASOMOTOR ACTIVITY AND SHIVERING IN RATS
LATERAL DISTRIBUTION OF HYPOTHALAMIC SIGNALS CONTROLLING THERMOREGULATORY VASOMOTOR ACTIVITY AND SHIVERING IN RATS
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DOI：
10.1152/ajpregu.1991.260.3.r486
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发表时间：
1991-03-01
影响因子：
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通讯作者：
MATSUMURA, K
中科院分区：
文献类型：
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作者：
KANOSUE, K;NIWA, K;MATSUMURA, K
本研究通过测量单侧视前区和下丘脑前部（POAH）加温和电刺激以及单侧腹部皮肤热刺激时，大鼠足爪皮肤血管活性和后肢肌肉冷诱导颤抖，探讨了中枢神经温度调节控制的偏侧性。单侧POAH加温使身体两侧血管舒张，但同侧血管舒张总是发生在下丘脑温度阈值较低时或比对侧更强。在寒冷的环境中（5 ℃），当POAH的一侧被加热时，颤抖在两条后腿中同时被抑制，并且当POAH加热停止时，颤抖在两侧同时重新出现。这些结果表明，不同的温度调节效应器以不同的方式由POAH的每一侧进行调节。另一方面，腹部皮肤的单侧热刺激会影响身体两侧的血管活性和颤抖，正如先前报道的那样，它会影响唾液分泌。因此，来自身体两侧的皮肤热信号在作用于不同的体温调节效应器系统之前似乎会会聚。
The present study explored the laterality of central nervous thermoregulatory control in anesthetized rats by measuring paw skin vasomotor activity and cold-induced shivering in hind leg muscles during unilateral preoptic area and anterior hypothalamus (POAH) warming and electrical stimulation or during unilateral thermal stimulation of abdominal skin. Unilateral POAH warming produced vasodilation on both sides of the body, but vasodilation on the ipsilateral side always either occurred at a lower threshold hypothalamic temperature or was stronger than on the contralateral side. In a cold environment (5-degrees-C), shivering was suppressed simultaneously in both hind legs when one side of the POAH was warmed, and shivering reappeared simultaneously on both sides when POAH warming stopped. These results suggest that different thermoregulatory effectors are regulated in a different way by each side of the POAH. Unilateral thermal stimulation of the abdominal skin, on the other hand, affected vasomotor activity and shivering equally on both sides of the body, as previously reported for its influence on salivary secretion. Skin thermal signals from both sides of the body therefore seem to converge before they act on different thermoregulatory effector systems.