Replication Proteins and Human Disease
Replication Proteins and Human Disease
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DOI：
10.1101/cshperspect.a013060
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发表时间：
2014-01-01
影响因子：
7.2
通讯作者：
Coleman, Nicholas
中科院分区：
文献类型：
--
作者：
Jackson, Andrew P.;Laskey, Ronald A.;Coleman, Nicholas
在这篇文章中，我们讨论了DNA复制蛋白在人类疾病中的意义。在编码复制蛋白的基因中存在广泛的突变，其导致几种具有共同主题的不同临床病症。一组复制蛋白，MCMs，已经成为早期检测一系列常见癌症的有效生物标志物。与其他复制蛋白相比，它们具有实际和理论上的优势，并已被开发用于广泛的临床应用。
In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerged as effective biomarkers for early detection of a range of common cancers. They offer practical and theoretical advantages over other replication proteins and have been developed for widespread clinical use.