Immuno-modulator inter-alpha inhibitor proteins ameliorate complex auditory processing deficits in rats with neonatal hypoxic-ischemic brain injury.
Immuno-modulator inter-alpha inhibitor proteins ameliorate complex auditory processing deficits in rats with neonatal hypoxic-ischemic brain injury.
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DOI：
10.1016/j.bbi.2017.03.004
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Stonestreet BS
中科院分区：
文献类型：
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作者：
Threlkeld SW;Lim YP;La Rue M;Gaudet C;Stonestreet BS
缺氧缺血性（HI）脑损伤被认为是围产期的一个重要问题，导致终身语言学习和其他认知障碍。中枢听觉处理缺陷在缺氧缺血性脑病婴儿中很常见，并已被证明可预测其他高危婴儿群体的语言学习缺陷。α-间抑制蛋白（IAIP）是一个结构相关的血浆蛋白家族，可调节对感染的全身炎症反应，并已显示可减轻新生大鼠脑损伤后的细胞死亡和改善学习结果。在这里，我们表明，在早期HI损伤级联系统管理IAIP改善复杂的听觉辨别缺陷相比，未经治疗的HI损伤的主题，尽管减少脑重量。这些发现对改善HI相关脑损伤新生儿与语言学习相关的中枢听觉处理缺陷具有重要的临床意义。
Hypoxic-ischemic (HI) brain injury is recognized as a significant problem in the perinatal period, contributing to life-long language-learning and other cognitive impairments. Central auditory processing deficits are common in infants with hypoxic-ischemic encephalopathy and have been shown to predict language learning deficits in other at risk infant populations. Inter-alpha inhibitor proteins (IAIPs) are a family of structurally related plasma proteins that modulate the systemic inflammatory response to infection and have been shown to attenuate cell death and improve learning outcomes after neonatal brain injury in rats. Here, we show that systemic administration of IAIPs during the early HI injury cascade ameliorates complex auditory discrimination deficits as compared to untreated HI injured subjects, despite reductions in brain weight. These findings have significant clinical implications for improving central auditory processing deficits linked to language learning in neonates with HI related brain injury.