The patched gene in development and cancer
The patched gene in development and cancer
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DOI：
10.1016/s0959-437x(98)80067-1
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发表时间：
1998-02-01
影响因子：
4
通讯作者：
Ingham, PW
中科院分区：
文献类型：
--
作者：
Ingham, PW
果蝇节极性基因补丁的脊椎动物同源物的克隆已导致确认的作用，它编码的多通道跨膜蛋白作为受体的刺猬家族的分泌信号蛋白。此外，人类patched已被确定为与基底细胞癌和髓母细胞瘤有关的肿瘤抑制基因。
The cloning of vertebrate homologues of the Drosophila segment polarity gene patched has led to confirmation of a role for the multipass transmembrane protein which it encodes as a receptor for secreted signalling proteins of the Hedgehog family. In addition, human patched has been identified as a tumour suppressor gene implicated in basal cell carcinomas and medullablastomas.