Left ventricular mechanics during synchronous left atrial-aortic bypass.
Left ventricular mechanics during synchronous left atrial-aortic bypass.
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同步左心房-主动脉搭桥期间的左心室力学。
DOI：
10.1016/s0022-5223(94)70431-7
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
W. Pierce
中科院分区：
文献类型：
--
作者：
O. Kawaguchi;J. Sapirstein;W. B. Daily;W. Pae;W. Pierce
本研究的目的是通过压力-容积关系分析微球注射前后非同步搏动性左房-主动脉转流中的左心室力学。在14头麻醉的荷斯坦犊牛中，用微压计测量左心室压力，用超声尺寸传感器测量左心室正交直径。使用椭圆体几何形状来计算同时左心室容积。收缩指数，压力-容积面积，外功和势能计算在稳态收缩。在搏动性左心房-主动脉搭桥术期间重复这些测量。为了诱导心力衰竭，我们将微球注射到左冠状动脉主干中，并重复基线和搏动性左心房-主动脉旁路术的方案。尽管基线收缩指数存在显著差异（7.4 ± 0.7 mm Hg/ml vs 4.7 ± 0.5 mm Hg/ml），但在对照和心力衰竭模式下，搏动性左心房-主动脉旁路术期间收缩指数分别保持不变。搏动性左房主动脉旁路术在对照组和心力衰竭组分别显著降低舒张末期容积（22%和17%）、压力-容积面积（58%和48%）和外功（74%和69%，allp <0.05）。然而，它并没有改变收缩末期容积或势能。总之，非同步搏动性左心房-主动脉旁路术对正常或衰竭心脏的左心室收缩状态均无影响。虽然压力-容积面积的减少可以解释心肌耗氧量的减少，但势能不变表明心室的负荷有限。
The purpose of this study was to analyze left ventricular mechanics during asynchronous, pulsatile left atrial-aortic bypass before and after microsphere injection with the pressure-volume relationship. In 14 anesthetized Holstein calves, left ventricular pressure was measured with a micromanometer and ultrasonic dimension transducers measured left ventricular orthogonal diameters. Ellipsoidal geometry was used to calculate simultaneous left ventricular volume. Contractility index, pressure-volume area, external work, and potential energy were calculated during steady-state contractions. These measurements were repeated during pulsatile left atrial-aortic bypass. To induce heart failure, we injected microspheres into the left main coronary artery, and the protocol for baseline and pulsatile left atrial-aortic bypass was repeated. Despite the significant differences in the baseline contractility index (7.4 ± 0.7 mm Hg/ml versus 4.7 ± 0.5 mm Hg/ml), contractility index remained the same during pulsatile left atrial-aortic bypass in control and heart failure modes, respectively. Pulsatile left atrialaortic bypass significantly decreased end-diastolic volume (22 % and 17 %), pressure-volume area (58 % and 48 %) and external work (74 % and 69 %, allp< 0.05) during control and heart failure measurements, respectively. However, it did not change end-systolic volume or potential energy. In conclusion, asynchronous pulsatile left atrial-aortic bypass did not affect left ventricular contractile state in either the normal or failing heart. Although decreased pressure-volume area accounts for the reduction in myocardial oxygen consumption, unchanged potential energy suggested a limited unloading of the ventricle.
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DOI：
--
发表时间：
1986
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Grossi,EA;Krieger,KH;CunninghamJr,JN;Laschinger,JC;Weiss,MR;Nathan,IM;Hunter,CE;Spencer,FC
通讯作者：
Spencer,FC
影响因子：
37.8
作者：
GLOWER, DD;SPRATT, JA;RANKIN, JS
通讯作者：
RANKIN, JS
影响因子：
37.8
作者：
KASS, DA;YAMAZAKI, T;SAGAWA, K
通讯作者：
SAGAWA, K
左心室循环辅助期间缺血后心脏射血的左心室力学。
DOI：
--
发表时间：
1991
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Ratcliffe,MB;Bavaria,JE;Wenger,RK;Bogen,DK;EdmundsJr,LH
通讯作者：
EdmundsJr,LH