CHRONICALLY DECEREBRATE RATS DEMONSTRATE SATIATION BUT NOT BAIT SHYNESS
CHRONICALLY DECEREBRATE RATS DEMONSTRATE SATIATION BUT NOT BAIT SHYNESS
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DOI：
10.1126/science.663655
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
NORGREN, R
中科院分区：
文献类型：
--
作者：
GRILL, HJ;NORGREN, R
应用于口腔的味觉物质导致摄入或排斥，每种都具有特征性的肌肉反应模式。这些反应在去大脑和完整大鼠中是相同的;尾侧脑干似乎是摄食和排斥反应的神经基质。该实验确定了去脑动物是否可以改变这些作为食物剥夺或中毒的功能的区别性反应。食物剥夺的去大脑大鼠，像完整的大鼠一样，摄入了它们在饱足时拒绝的味道物质。与对照组相比，这些去脑动物在重复将一种新味道与氯化锂诱发的疾病配对后，既不排斥也不减少对这种味道的摄食反应。虽然前脑可能是重要的整合摄入，这种控制的某些方面似乎是在尾脑区。
Taste substances applied to the oral cavity result in either ingestion or rejection, each with a characteristic muscular response pattern. These responses are the same in decerebrate and intact rats; the caudal brainstem appears to be the neural substrate of ingestion and rejection responses. The experiment determined whether decerebrates can alter these discriminative responses as a function of food deprivation or toxicosis. Food-deprived decerebrate rats, like intact ones, ingested a taste substrance they had rejected when sated. These same decerebrates, in contrast to controls, neither rejected nor decreased ingestive reactions to a novel taste after that taste had been repeatedly paired with lithium chloride-induced illness. Although the forebrain may be important for integrating ingestion, some aspects of this control seem to be represented in caudal brain areas.