Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials
Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials
复制标题
DOI：
10.1016/j.jalz.2019.03.005
复制
发表时间：
2019-06-01
影响因子：
14
通讯作者：
Willis, Sherry
中科院分区：
文献类型：
--
作者：
Coley, Nicola;Ngandu, Tiia;Willis, Sherry
简介：多领域的干预措施，同时针对多种危险因素，可能是有效的痴呆症预防策略，但可能是繁重的，并不普遍accepted.Methods：我们研究了遵守率和预测因素在芬兰老年干预研究，以防止认知障碍和残疾和多领域阿尔茨海默病预防试验预防试验，所有的干预组件（单独和同时）。芬兰预防认知障碍和残疾的老年干预研究参与者接受了为期2年的多领域生活方式干预（体育训练，认知训练，营养咨询和心血管监测）。多域阿尔茨海默病预防试验的参与者接受了3年的多域生活方式干预（认知训练，体育活动咨询，营养咨询）与ω-3补充剂或安慰剂。结果：依从性下降，增加干预的复杂性和强度：它是最高的心血管监测，营养咨询，ω-3补充剂，和最低的无监督的计算机为基础的认知训练。最一致的基线预测的依从性吸烟和抑郁symptoms.Discussion：减少参与者的负担，同时确保技术工具是适合老年人，保持面对面的接触，并考虑到参与者的特点可能会增加在未来的试验中的依从性。(C)2019年，阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Introduction: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable.Methods: We studied adherence rates and predictors in the Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability and Multidomain Alzheimer Preventive Trial prevention trials, for all intervention components (separately and simultaneously). Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability participants received a 2-year multidomain lifestyle intervention (physical training, cognitive training, nutritional counseling, and cardiovascular monitoring). Multidomain Alzheimer Preventive Trial participants received a 3-year multidomain lifestyle intervention (cognitive training, physical activity counseling, and nutritional counseling) with either an omega-3 supplement or placebo.Results: Adherence decreased with increasing intervention complexity and intensity: it was highest for cardiovascular monitoring, nutritional counseling, and the omega-3 supplement, and lowest for unsupervised computer-based cognitive training. The most consistent baseline predictors of adherence were smoking and depressive symptoms.Discussion: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.