Quality of life in patients with multiple sclerosis: the impact of depression, fatigue, and disability
Quality of life in patients with multiple sclerosis: the impact of depression, fatigue, and disability
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DOI：
10.1097/mrr.0b013e32834ad479
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发表时间：
2011-12-01
影响因子：
1.7
通讯作者：
Gedizlioglu, Muhtesem
中科院分区：
文献类型：
--
作者：
Karatepe, Altlnay Goksel;Kaya, Taciser;Gedizlioglu, Muhtesem
目的本研究的目的是评估生活质量（QoL）在多发性硬化症（MS）患者，并评估其与残疾和心理社会因素，特别是抑郁和fatigue.Methods人口统计学特征，教育水平，疾病严重程度和疾病持续时间记录为每个病人。采用多发性硬化生活质量-54量表、疲劳严重程度量表、简易精神状态量表和Beck抑郁量表分别评估患者的生活质量、疲劳程度、认知状态和抑郁程度。MS患者的生活质量评分存在中度损害。生活质量受影响最大的部分包括：角色限制相关的身体和情绪问题以及身体和社会功能。身体和心理健康的QoL组件显示出正相关的教育水平和就业状况，残疾，疲劳和抑郁的水平呈负相关。抑郁症，残疾水平，疲劳是最强的变量与生活质量，和生活质量的最重要的预测是depression.Conclusion我们的研究结果表明，身体和精神健康的生活质量的组成部分受到MS的负面影响。生活质量的最重要的预测是抑郁症，其次是残疾和疲劳。为改善MS患者的生活质量，除躯体残疾外，还应考虑抑郁和疲劳对生活质量的影响。
Aim The aim of this study was to assess the quality of life (QoL) in patients with multiple sclerosis (MS), and to evaluate its association with disability and psychosocial factors especially depression and fatigue.Methods Demographic characteristics, education level, disease severity, and disease duration were documented for each patient. QoL, fatigue level, cognitive status, and depression level of patients were assessed by Multiple Sclerosis Quality of Life-54, Fatigue Severity Scale, Mini Mental State Scale, and Beck Depression Inventory, respectively.Results Seventy-nine patients with MS were included in the study. There was a moderate degree of impairment in the QoL scores of MS patients. The most affected parts of QoL were included: role limitation-related physical and emotional problems and physical and social functions. Both physical and mental health components of QoL showed a positive correlation with the educational level and employment status; a negative correlation with the level of disability, fatigue, and depression. Depression, disability level, and fatigue were the strongest variables associated with QoL, and the most important predictor of QoL was depression.Conclusion Our results have shown that both physical and mental health components of QoL were negatively affected by MS. The most important predictor of QoL was depression followed by disability and fatigue. To improve the QoL for MS patients, in addition to physical disability, the influences of depression and fatigue on QoL should be taken into consideration.