Splanchnic hemodynamics and gut mucosal-arterial Pco2 gradient during systemic hypocapnia
Splanchnic hemodynamics and gut mucosal-arterial Pco2 gradient during systemic hypocapnia
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DOI：
10.1152/jappl.1999.87.3.1102
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发表时间：
1999-09-01
影响因子：
3.3
通讯作者：
Kruse, JA
中科院分区：
文献类型：
--
作者：
Guzman, JA;Kruse, JA
在7只麻醉通气的狗上研究了低碳酸血症[动脉PCO_2（Pa-CO_2）15 Torr]对内脏血流动力学和肠粘膜-动脉P-CO_2的影响。回肠粘膜和浆膜血流量估计使用激光多普勒血流仪，粘膜PCO 2连续测量使用二氧化碳循环气体张力计，和浆膜表面PO 2使用极谱电极进行评估。通过去除死腔诱导低碳酸血症，并维持45分钟，然后维持45分钟的正常碳酸血症。基线时的平均Pa-CO2为38.1 +/- 1.1（SE）Torr，去除死腔后降至13.8 +/- 1.3 Torr。低碳酸血症时心输出量及门脉血流量显著降低。同样，粘膜和浆膜血流量分别减少15 +/- 4和34 +/-7%。此外，在低碳酸血症时观察到粘膜-动脉PCO 2梯度增加10.7 Torr，血清PO 2降低30 Torr（水浴P < 0.01）。低碳酸血症引起回肠粘膜和浆膜灌注不足，血流重新分布有利于粘膜，伴随PCO 2梯度增加和浆膜PO 2减少。
The effects of hypocapnia [arterial PCO2 (Pa-CO2) 15 Torr] on splanchnic hemodynamics and gut mucosal-arterial P-CO2 were studied in seven anesthetized ventilated dogs. Ileal mucosal and serosal blood flow were estimated by using laser Doppler flowmetry, mucosal PCO2 was measured continuously by using capnometric recirculating gas tonometry, and serosal surface PO2 was assessed by using a polarographic electrode. Hypocapnia was induced by removal of dead space and was maintained for 45 min, followed by 45 min of eucapnia. Mean Pa-CO2 at baseline was 38.1 +/- 1.1 (SE) Torr and decreased to 13.8 +/- 1.3 Torr after removal of dead space. Cardiac output and portal blood flow decreased significantly with hypocapnia. Similarly, mucosal and serosal blood flow decreased by 15 +/- 4 and by 34 +/- 7%, respectively. Also, an increase in the mucosal-arterial PCO2 gradient of 10.7 Torr and a reduction in serosal PO2 of 30 Torr were observed with hypocapnia (P < 0.01 for bath). Hypocapnia caused ileal mucosal and serosal hypoperfusion, with redistribution of flow favoring the mucosa, accompanied by increased PCO2 gradient and diminished serosal PO2.