Reference values for cystatin C serum concentrations in children
Reference values for cystatin C serum concentrations in children
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DOI：
10.1007/s004670050419
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发表时间：
1998-02-01
影响因子：
3
通讯作者：
Brodehl, J
中科院分区：
文献类型：
--
作者：
Bökenkamp, A;Domanetzki, M;Brodehl, J
半胱氨酸蛋白酶抑制剂C是一种低分子量蛋白质，是一种新的肾功能内源性标志物，其血清浓度与肾小球滤过率的相关性比肌酸酐更好。本研究的目的是确定儿童胱抑素C浓度的参考区间。通过免疫比浊法测定258名无肾脏疾病证据的儿童（93名女孩，165名男孩，中位年龄6.29岁，范围1天至18岁）的血清中的胱抑素C。使用第2.5和第97.5位数非参数计算参考区间。为了比较，在相同的样品中测量肌酸酐。半胱氨酸蛋白酶抑制剂C浓度在出生后第一天最高（范围1.64-2.59 mg/l），在前4个月内迅速下降，超过1岁，半胱氨酸蛋白酶抑制剂C浓度保持恒定，参考区间为0.7-1.38 mg/l。相反，血清肌酐浓度随着年龄的增长而稳步增加，直到成年。与肌酐相比，半胱氨酸蛋白酶抑制剂C有助于识别儿童肾功能异常，因为其参考范围在生命的第一年之后是恒定的。新生儿和婴儿在出生后第1年较高的胱抑素C水平可能反映了其肾小球滤过率较低。
Cystatin C, a low molecular weight protein, is a new endogenous marker of renal function whose serum concentration correlates better with glomerular filtration rate than creatinine. The aim of the present study was to define a reference interval for cystatin C concentrations in children. Cystatin C was measured by an immunoturbidimetric assay in sera obtained from 258 children (93 girls, 165 boys, median age 6.29 years, range 1 day to 18 years) without evidence of kidney disease. The reference interval was calculated non-parametrically using the 2.5th and 97.5th percentiles. For comparison, creatinine was measured in the same samples. The cystatin C concentration was highest on the first days of life (range 1.64-2.59 mg/l) with a rapid decrease during the first 4 months, Beyond the Ist year, the cystatin C concentration was constant, with a reference interval of 0.7-1.38 mg/l. In contrast, serum creatinine concentrations steadily increased with age until adulthood. Compared with creatinine, cystatin C facilitates the recognition of abnormal renal function in children as its reference range is constant beyond the Ist year of life. The higher levels of cystatin C in the Ist year of life probably reflect the low glomerular filtration rate of neonates and infants.