Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss
Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss
复制标题
DOI：
10.1016/j.febslet.2006.01.038
复制
发表时间：
2006-02-01
期刊：
影响因子：
3.5
通讯作者：
Minami, A
中科院分区：
文献类型：
--
作者：
Oshima, S;Onodera, S;Minami, A
最近发现巨噬细胞迁移抑制因子（MIF）和雌激素之间存在联系。我们检查了 MIF 在卵巢切除 (OVX) 后骨骨质疏松变化中的参与情况，并发现 MIF 缺陷小鼠 (MIF-KO) 完全免受这种现象的影响。在野生型小鼠 OVX 后观察到的每骨表面破骨细胞数量和血清 IL1 β 水平的增加，在 MIF KO 中并未出现。我们的数据表明，MIF 在绝经后骨质疏松症的发病机制中发挥着重要作用，并可能成为治疗该疾病的新靶点。 (c) 2006 年欧洲生化学会联合会。由 Elsevier B.V. 出版。保留所有权利。
A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL1 beta levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.