Can the E-Field Help Translate Repolarization From Bench to Bedside?
Can the E-Field Help Translate Repolarization From Bench to Bedside?
复制标题
电场可以帮助将复极从实验室转移到临床吗？
DOI：
10.1016/j.jacep.2023.04.025
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ziv,Ohad
中科院分区：
文献类型：
--
作者：
Laurita,KennethR;Ziv,Ohad
复极的空间异质性是可再入性心律失常的长期和公认的基础，并且在大多数心脏疾病中显著增加。尽管如此，确定体内复极异质性，特别是在人类中，仍然没有很好地建立。因此，将体内和离体动物模型的发现转化为人类是非常具有挑战性的，这些模型有其众所周知的局限性。在这一期的《JACC：临床电生理学》中，Vermoortele等人利用一种新的电场方法改进了体内复极化异质性的测定，该方法可以推导出激活时间（AT）和复极化时间（RT）。
Spatial heterogeneity of repolarization is a long-standing and well-recognized substrate for reentrant arrhythmias, and it is significantly increased in most cardiac diseases. Despite this, determining repolarization heterogeneity in vivo, especially in humans, is still not well established. Consequently, translating discoveries from in vivo and ex vivo animal models, which have their own well-recognized limitations, to humans is very challenging. 1 In this issue of JACC: Clinical Electrophysiology, Vermoortele et al 2 aim to improve the determination of repolarization heterogeneity in vivo using a novel E-field method from which activation time (AT) and repolarization time (RT) are derived.