The origin of cerebellar-induced inhibition of Deiters neurones I. Monosynaptic initiation of the inhibitory postsynaptic potentials
The origin of cerebellar-induced inhibition of Deiters neurones I. Monosynaptic initiation of the inhibitory postsynaptic potentials
复制标题
小脑诱导的 Deiters 神经元抑制的起源 I. 抑制性突触后电位的单突触起始
DOI：
10.1007/bf00234779
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发表时间：
2004
影响因子：
2
通讯作者：
M. Yoshida
中科院分区：
文献类型：
--
作者：
M. Ito;M. Yoshida
在刺激小脑前叶的过程中，记录了猫同侧deiter神经元的细胞内突触后电位。在大多数被检测的细胞中，抑制性突触后电位以短潜伏期诱导；III小叶和IV小叶的潜伏期平均为1.06 msec。V小叶的潜伏期较长（1.23 msec），而束旁小叶的潜伏期较短（0.86 msec）。由此可见，IPSP是通过单突触通路以15 ~ 20 m/sec的传导速度产生的。细胞外场电位的记录和deiter核内及周围的局部刺激进一步表明，抑制脉冲沿着一束显著的纤维从小脑传播出去，并在deiter核内终止。这些结果都可以通过假设小脑浦肯野细胞在本质上是抑制性的，因此通过长皮质纤维在deiter神经元中单突触产生ipsp来解释。在一些deiter神经元中也检测到单突触epsp。它们被认为是由小脑传入事件轴突侧枝形成的其他通路介导的。
SummaryDuring stimulation of the anterior lobe of the cerebellum, postsynaptic potentials were recorded intracellularly from ipsilateral Deiters neurones of the cat. In the majority of examined cells, the inhibitory postsynapic potentials were induced with short latency; 1.06 msec on the average from lobule III or IV. The latency was longer (1.23 msec) when the lobule V was stimulated, while it was shorter (0.86 msec) from the juxtafastigial region. It follows that the IPSP was produced via a monosynaptic pathway at a conduction velocity of 15 to 20 m/sec. Recording of the extracellular field potentials and focal stimulation within and around Deiters' nucleus further indicated that the inhibitory impulses propagated out of the cerebellum along a remarkable bundle of fibres which terminated within Deiters' nucleus. These results are all explicable by assuming that the cerebellar Purkinje cells are inhibitory in nature and so produce IPSPs monosynaptically in Deiters neurones via the long corticofugal fibres. Monosynaptic EPSPs were also detected in some Deiters neurones. They are considered to be mediated by the other pathways formed of axon collaterals of the cerebellar afferents.