The role of visual experience in the development of columns in cat visual cortex
The role of visual experience in the development of columns in cat visual cortex
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DOI：
10.1126/science.279.5350.566
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发表时间：
1998-01-23
期刊：
影响因子：
56.9
通讯作者：
Stryker, MP
中科院分区：
文献类型：
--
作者：
Crair, MC;Gillespie, DC;Stryker, MP
长期以来，经验在大脑皮层发育中的作用一直存在争议。猫的模式化视觉体验在出生后一周左右眼睛睁开时开始。皮质地图的方向和眼优势在猫的初级视觉皮层被发现存在2周。早期模式视觉似乎并不重要，因为这些皮质地图直到近3周龄时才完全相同，无论眼睛是否睁开。对侧眼强烈地主导了幼稚地图，并且需要经验来使对另一只眼的反应变得强烈，这一过程不太可能是严格的赫布过程。随着持续的视觉剥夺，对双眼的反应恶化，其时间过程与众所周知的皮质可塑性关键期平行。因此，皮层地图的基本结构是先天的，但经验对于这些地图的特定功能以及维持皮层神经元的反应性和选择性至关重要。
The role of experience in the development of the cerebral cortex has long been controversial. Patterned visual experience in the cat begins when the eyes open about a week after birth. Cortical maps for orientation and ocular dominance in the primary visual cortex of cats were found to be present by 2 weeks. Early pattern vision appeared unimportant because these cortical maps developed identically until nearly 3 weeks of age, whether or not the eyes were open. The naive maps were powerfully dominated by the contralateral eye, and experience was needed for responses to the other eye to become strong, a process unlikely to be strictly Hebbian, With continued visual deprivation, responses to both eyes deteriorated, with a time course parallel to the well-known critical period of cortical plasticity. The basic structure of cortical maps is therefore innate, but experience is essential for specific features of these maps, as well as for maintaining the responsiveness and selectivity of cortical neurons.