Self-Control in Decision-Making Involves Modulation of the vmPFC Valuation System
Self-Control in Decision-Making Involves Modulation of the vmPFC Valuation System
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DOI：
10.1126/science.1168450
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发表时间：
2009-05-01
期刊：
影响因子：
56.9
通讯作者：
Rangel, Antonio
中科院分区：
文献类型：
--
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
每天，人们都要在一个整体价值更高的替代品和一个更诱人但最终更差的选择之间做出几十个选择。最佳决策需要自我控制。我们提出了两个假设自我控制的神经生物学：（一）目标导向的决定有其基础上的共同价值信号编码在腹内侧前额叶皮层（vmPFC），和（ii）行使自我控制涉及调制这个价值信号的背外侧前额叶皮层（DLPFC）。我们使用功能性磁共振成像来监测节食者在做出真实的食物消费决定时的大脑活动。在vmPFC活动与目标值无关的自我控制的金额。它在自我控制者身上融合了品味和健康，但在非自我控制者身上只融合了品味。当受试者进行自我控制时，DLPFC的活动增加，并与VMPFC的活动相关。
Every day, individuals make dozens of choices between an alternative with higher overall value and a more tempting but ultimately inferior option. Optimal decision-making requires self-control. We propose two hypotheses about the neurobiology of self-control: (i) Goal-directed decisions have their basis in a common value signal encoded in ventromedial prefrontal cortex (vmPFC), and (ii) exercising self-control involves the modulation of this value signal by dorsolateral prefrontal cortex (DLPFC). We used functional magnetic resonance imaging to monitor brain activity while dieters engaged in real decisions about food consumption. Activity in vmPFC was correlated with goal values regardless of the amount of self-control. It incorporated both taste and health in self-controllers but only taste in non-self-controllers. Activity in DLPFC increased when subjects exercised self-control and correlated with activity in vmPFC.