GENOMIC ENVIRONMENT OF T-BRUCEI VSG GENES - PRESENCE OF A MINICHROMOSOME
GENOMIC ENVIRONMENT OF T-BRUCEI VSG GENES - PRESENCE OF A MINICHROMOSOME
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DOI：
10.1038/299417a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
MAJIWA, PAO
中科院分区：
文献类型：
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作者：
WILLIAMS, RO;YOUNG, JR;MAJIWA, PAO
一些锥虫变异体表面糖蛋白（VSG）基因的限制性内切酶图谱在基因的3“处有一个位点，许多酶似乎在该位点切割。该位点对Bal31核酸外切酶敏感，表明DNA中存在天然双链断裂。一个VSG基因作为非整合的微型染色体存在于几个细胞克隆中。
Restriction endonuclease maps of some trypanosome variant surface glycoprotein (VSG) genes have a site 3'' to the gene where many enzymes appear to cut. This site is sensitive to Bal31 exonuclease, indicating a natural double-strand break in the DNA. One VSG gene exists in several cell clones as a non-integrated minichromosome.