A review of studies on the effect of iron deficiency on cognitive development in children
A review of studies on the effect of iron deficiency on cognitive development in children
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DOI：
10.1093/jn/131.2.649s
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发表时间：
2001-02-01
影响因子：
4.2
通讯作者：
Ani, C
中科院分区：
文献类型：
--
作者：
Grantham-McGregor, S;Ani, C
铁缺乏对儿童的认知和行为的影响的研究进行了选择性审查，寻找因果关系的证据。大多数相关性研究发现缺铁性贫血与认知和运动发育不良以及行为问题之间存在关联。纵向研究一致表明，在婴儿期贫血的儿童继续有较差的认知，学习成绩，和更多的行为问题，进入童年中期。然而，贫困的社会经济背景可能产生的混杂效应阻止了因果关系的推断。在2岁贫血儿童中，来自RCT的证据具有合理的说服力，但不是决定性的。铁治疗的随机对照试验是必要的，特别是在年幼的儿童。
Studies on the effect of iron deficiency on children's cognition and behavior are selectively reviewed, looking for evidence of a causal relationship. Most correlational studies have found associations between iron-deficiency anemia and poor cognitive and motor development and behavioral problems. Longitudinal studies consistently indicate that children anemic in infancy continue to have poorer cognition, school achievement, and more behavior problems into middle childhood. However, the possible confounding effects of poor socioeconomic backgrounds prevent causal inferences from being made. In anemic children 2 y old, the evidence from RCT is reasonably convincing but not conclusive. RCT of iron treatment are warranted especially in younger children.