Fitness Correlates of Heritable Variation in Antibody Responsiveness in a Wild Mammal
Fitness Correlates of Heritable Variation in Antibody Responsiveness in a Wild Mammal
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DOI：
10.1126/science.1194878
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发表时间：
2010-10-29
期刊：
影响因子：
56.9
通讯作者：
Nussey, Daniel H.
中科院分区：
文献类型：
--
作者：
Graham, Andrea L.;Hayward, Adam D.;Nussey, Daniel H.
正常的免疫系统对于在自然环境中的生存非常重要，在自然环境中，个人经常接触寄生虫。然而，如果强烈的免疫反应耗尽了有限的能量资源或导致自身免疫性疾病，那么它们可能会导致健康成本。我们在大豆羊的野生种群中发现了健康和可遗传的自身反应性抗体反应性之间的关联。自身反应性抗体的出现与总体抗体反应性相关，并与成年男女生殖减少有关。然而，在雌性中，自身反应性抗体的存在与成年动物在严寒冬季的存活呈正相关。我们的结果突出了自然选择对免疫反应性的复杂影响，并表明适应性权衡可能保持免疫异质性，包括自身免疫易感性的遗传变异。
A functional immune system is important for survival in natural environments, where individuals are frequently exposed to parasites. Yet strong immune responses may have fitness costs if they deplete limited energetic resources or cause autoimmune disease. We have found associations between fitness and heritable self-reactive antibody responsiveness in a wild population of Soay sheep. The occurrence of self-reactive antibodies correlated with overall antibody responsiveness and was associated with reduced reproduction in adults of both sexes. However, in females, the presence of self-reactive antibodies was positively associated with adult survival during harsh winters. Our results highlight the complex effects of natural selection on immune responsiveness and suggest that fitness trade-offs may maintain immunoheterogeneity, including genetic variation in autoimmune susceptibility.